Chimeric antigen receptor T-cell therapies for cancer: a practical guide

Lee, Daniel W.

Chimeric antigen receptor T-cell therapies for cancer: a practical guide - Amsterdam : Elsevier, 2020 - 1 online resource (xi, 222 pages):illustrations(chiefly color)

Introduction -- When to refer a patient for CAR-T cell therapy -- Optimizing the apheresis product -- CAR T cells: cell processing laboratory considerations -- Peri-CAR-T cell management -- Management of cytokine release syndrome -- Special considerations for ICU management of patients receiving CAR therapy -- Neurotoxicities after CAR-T cell immunotherapy -- Hematologic and non-CRS toxicities -- Response assessment and post-CAR-T cell therapy management -- Relapse management and role for consolidative hematopoietic stem cell transplantation following CAR-T cell therapy -- Promising chimeric antigen receptors for non-B cell hematological malignancies, pediatric solid tumors, and carcinomas -- CAR T cell therapy for CNS malignancies -- CAR 2.0: the next generation of synthetic receptor-based cellular therapy for cancer.

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