Coexistent asymptomatic myeloma and hereditary cardiac amyloidosis: an unusual case of heart failure. (Record no. 75372)
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| 000 -LEADER | |
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| fixed length control field | 01654cam a2200217 4500 |
| 001 - CONTROL NUMBER | |
| control field | NMDX5855 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 120401t2011 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 17508460 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Lee, L. |
| 240 ## - UNIFORM TITLE | |
| Uniform title | <a href="British Journal of Hospital Medicine">British Journal of Hospital Medicine</a> |
| 245 ## - TITLE STATEMENT | |
| Title | Coexistent asymptomatic myeloma and hereditary cardiac amyloidosis: an unusual case of heart failure. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc. | 2011 |
| 500 ## - GENERAL NOTE | |
| General note | NMUH Staff Publications |
| 500 ## - GENERAL NOTE | |
| General note | 72 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | A 76-year-old Afro-Caribbean man presenting with heart failure was diagnosed with isolated cardiac amyloid. He had evidence of myeloma on bone marrow biopsy suggesting AL amyloid, the commonest type of systemic amyloidosis, as the underlying cause. He had no other myeloma-related organ damage. However, endocardial biopsy revealed amyloid fibrils composed of transthyretin and genetic typing established heterozygozity for the valine to isoleucine mutation at position 122 (Val122Ile). The diagnosis was therefore hereditary systemic amyloidosis as a result of a genetic transthyretin variant (ATTR) causing cardiac amyloidosis and coexistent asymptomatic myeloma. This requires symptomatic treatment of heart failure only. This article discusses a rare cause of heart failure and uses this case to illustrate that histological confirmation of the amyloid-causing protein is essential. Mistaken assumption of AL amyloid could have resulted in inappropriate cytotoxic therapy targeting the plasma cell clone. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aziz, M. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wechalekar, A. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rabin, N. |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://www.ncbi.nlm.nih.gov/pubmed/22083004">https://www.ncbi.nlm.nih.gov/pubmed/22083004</a> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://ferriman.wufoo.com/forms/r7x3a7/">http://ferriman.wufoo.com/forms/r7x3a7/</a> |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection code | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Staff publications for NMDX | Ferriman information and Library Service (North Middlesex) | Ferriman information and Library Service (North Middlesex) | Shelves | 07/06/2022 | 07/06/2022 | 07/06/2022 | Book |