Diagnostic predictors of obesity-hypoventilation syndrome in patients suspected of having sleep disordered breathing. (Record no. 75396)

MARC details
000 -LEADER
fixed length control field 02255cam a2200217 4500
001 - CONTROL NUMBER
control field NMDX5881
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 120401t2013 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 15509389
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Macavei, VM.
240 ## - UNIFORM TITLE
Uniform title <a href="Journal of clinical sleep medicine">Journal of clinical sleep medicine</a>
245 ## - TITLE STATEMENT
Title Diagnostic predictors of obesity-hypoventilation syndrome in patients suspected of having sleep disordered breathing.
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Date of publication, distribution, etc. 2013
500 ## - GENERAL NOTE
General note NMUH Staff Publications
500 ## - GENERAL NOTE
General note 9
520 ## - SUMMARY, ETC.
Summary, etc. &lt;div&gt;&lt;p&gt;INTRODUCTION: Obesity-hypoventilation syndrome (OHS) is associated with significant morbidity and mortality and requires measurement of arterial pCO2 for diagnosis.&lt;/p&gt;&lt;p&gt;OBJECTIVE: To determine diagnostic predictors of OHS among obese patients with suspected obstructive sleep apnea/hypopnea syndrome (OSAHS).&lt;/p&gt;&lt;p&gt;METHODS: Retrospective analysis of data on 525 sleep clinic patients (mean age 51.4 ± 12.7 years; 65.7% males; mean BMI 34.5 ± 8.1). All patients had sleep studies, and arterialized capillary blood gases (CBG) were measured in obese subjects (BMI &amp;gt; 30 kg/m2).&lt;/p&gt;&lt;p&gt;RESULTS: Of 525 patients, 65.5% were obese, 37.2% were morbidly obese (BMI &amp;gt; 40 kg/m2); 52.3% had confirmed OSAHS. Hypercapnia (pCO2 &amp;gt; 6 kPa or 45 mm Hg) was present in 20.6% obese and 22.1% OSAHS patients. Analysis of OHS predictors showed significant correlations between pCO2 and BMI, FEV1, FVC, AHI, mean and minimum nocturnal SpO2, sleep time with SpO2 &amp;lt; 90%, pO2, and calculated HCO3 from the CBG. PO2 and HCO3 were independent predictors of OHS, explaining 27.7% of pCO2 variance (p &amp;lt; 0.0001). A calculated HCO3 cutoff &amp;gt; 27 mmol/L had 85.7% sensitivity and 89.5% specificity for diagnosis of OHS, with 68.1% positive and 95.9% negative predictive value.&lt;/p&gt;&lt;p&gt;CONCLUSION: We confirmed a high prevalence of OHS in obese OSAHS patients (22.1%) and high calculated HCO3 level (&amp;gt; 27 mmol/L) to be a sensitive and specific predictor for the diagnosis of OHS.&lt;/p&gt;&lt;/div&gt;
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Spurling, KJ.
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Loft, J.
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Makker, HK.
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://www.ncbi.nlm.nih.gov/pubmed/23997700?dopt=Abstract">http://www.ncbi.nlm.nih.gov/pubmed/23997700?dopt=Abstract</a>
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://europepmc.org/journals/920">http://europepmc.org/journals/920</a>
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        Staff publications for NMDX Ferriman information and Library Service (North Middlesex) Ferriman information and Library Service (North Middlesex) Shelves 07/06/2022   07/06/2022 07/06/2022 Book
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