Early and prolonged antiretroviral therapy is associated with an HIV-1-specific T-cell profile comparable to that of long-term non-progressors. (Record no. 75755)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04304cam a2200313 4500 |
| 001 - CONTROL NUMBER | |
| control field | NMDX6590 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 120401t2011 xxu||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Cellerai, C. |
| 240 ## - UNIFORM TITLE | |
| Uniform title | <a href="PLoS One.">PLoS One.</a> |
| 245 ## - TITLE STATEMENT | |
| Title | Early and prolonged antiretroviral therapy is associated with an HIV-1-specific T-cell profile comparable to that of long-term non-progressors. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc. | 2011 |
| 500 ## - GENERAL NOTE | |
| General note | NMUH Staff Publications |
| 500 ## - GENERAL NOTE | |
| General note | 6 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | <div style="line-height: 17.999801635742188px;"><h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;"><span style="font-size: 8pt;">BACKGROUND:</span></h4><p style="margin: 0px 0px 0.5em;"><span style="font-size: 8pt;">Intervention with&nbsp;<span class="highlight">antiretroviral</span>&nbsp;treatment (ART) and control of viral replication at the time of HIV-1 seroconversion may curtail cumulative immunological damage. We have therefore hypothesized that ART maintenance over a very&nbsp;<span class="highlight">prolonged</span>&nbsp;period in HIV-1 seroconverters could induce an immuno-virological status similar to that of HIV-1&nbsp;<span class="highlight">long-term</span>&nbsp;<span class="highlight">non-progressors</span>&nbsp;(LTNPs).</span></p><h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;"><span style="font-size: 8pt;">METHODOLOGY/PRINCIPAL FINDINGS:</span></h4><p style="margin: 0px 0px 0.5em;"><span style="font-size: 8pt;">We have investigated a cohort of 20 HIV-1 seroconverters on&nbsp;<span class="highlight">long-term</span>&nbsp;ART (LTTS) and compared it to one of 15 LTNPs. Residual viral replication and reservoirs in peripheral blood, as measured by cell-<span class="highlight">associated</span>&nbsp;HIV-1 RNA and DNA, respectively, were demonstrated to be similarly low in both cohorts. These two virologically matched cohorts were then comprehensively analysed by polychromatic flow cytometry for&nbsp;<span class="highlight">HIV-1-specific</span>&nbsp;CD4(+) and CD8(+)&nbsp;<span class="highlight">T-cell</span>&nbsp;functional&nbsp;<span class="highlight">profile</span>&nbsp;in terms of cytokine production and cytotoxic capacity using IFN-γ, IL-2, TNF-α production and perforin expression, respectively.&nbsp;<span class="highlight">Comparable</span>&nbsp;levels of highly polyfunctional&nbsp;<span class="highlight">HIV-1-specific</span>&nbsp;CD4(+) and CD8(+) T-cells were found in LTTS and LTNPs, with low perforin expression on&nbsp;<span class="highlight">HIV-1-specific</span>&nbsp;CD8(+) T-cells, consistent with a polyfunctional/non-cytotoxic&nbsp;<span class="highlight">profile</span>&nbsp;in a context of low viral burden.</span></p><h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;"><span style="font-size: 8pt;">CONCLUSIONS:</span></h4><p style="margin: 0px 0px 0.5em;"><span style="font-size: 8pt;">Our results indicate that&nbsp;<span class="highlight">prolonged</span>&nbsp;ART initiated at the time of HIV-1 seroconversion is&nbsp;<span class="highlight">associated</span>&nbsp;with immuno-virological features which resemble those of LTNPs, strengthening the recent emphasis on the positive impact of&nbsp;<span class="highlight">early</span>&nbsp;treatment initiation and paving the way for further interventions to promote virological control after treatment interruption.</span></p></div> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Harari, A. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stauss, H. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yerly, S. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Geretti, A.M. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Carroll, A. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yee, T. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ainsworth, J. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Williams, I. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sweeney, J. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Freedman, A. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Johnson, M. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pantaleo, G. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kinloch-de Loes, S. |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071718/pdf/pone.0018164.pdf">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071718/pdf/pone.0018164.pdf</a> |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection code | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Staff publications for NMDX | Ferriman information and Library Service (North Middlesex) | Ferriman information and Library Service (North Middlesex) | Shelves | 07/06/2022 | 07/06/2022 | 07/06/2022 | Book |