Incidence and predictors of bacterial infection in febrile children with sickle cell disease (Record no. 75988)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02388cam a2200217 4500 |
| 001 - CONTROL NUMBER | |
| control field | NMDX6972 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 120401t2015 xxu||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Morrissey, B.J. |
| 240 ## - UNIFORM TITLE | |
| Uniform title | <a href="Hemoglobin">Hemoglobin</a> |
| 245 ## - TITLE STATEMENT | |
| Title | Incidence and predictors of bacterial infection in febrile children with sickle cell disease |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc. | 2015 |
| 500 ## - GENERAL NOTE | |
| General note | NMUH Staff Publications |
| 500 ## - GENERAL NOTE | |
| General note | 39 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | <span style="font-size: 10pt;">Children with sickle cell disease are at increased risk of developing bacteremia and other serious bacterial infections. Fever is a common symptom in sickle cell disease and can also occur with sickle cell crises and viral infections. We aimed to evaluate the incidence and predictors of bacteremia and bacterial infection in children with sickle cell disease presenting with fever to a district hospital and sickle cell center in London. A retrospective analysis was performed on all attendances of children (aged under 16 years) with sickle cell disease presenting with a fever of 38.5 °C or higher over a 1-year period. Confirmed bacterial infection was defined as bacteremia, bacterial meningitis, urinary tract infection (UTI), pneumonia, osteomyelitis or other bacterial infection with positive identification of organism. Children were defined as having a suspected bacterial infection if a bacterial infection was suspected clinically, but no organism was identified. Over a 1-year period there were 88 episodes analyzed in 59 children. Bacteremia occurred in 3.4% of episodes and confirmed bacterial infection in 7.0%. Suspected bacterial infection occurred in 33.0%. One death occurred from Salmonella typhirium septicemia. C-reactive protein (CRP) level and white blood cell (WBC) count were both significantly associated with bacterial infection (p = 0.004 and 0.02, respectively.) In conclusion, bacterial infections continue to be a significant problem in children with sickle cell disease. C-reactive protein was significantly associated with bacterial infections, and could be included in clinical risk criteria for febrile children with sickle cell disease.</span> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bycroft, T.P. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Almossawi, Ofran |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wilkey, O.B. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Daniels, J. |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://www.ncbi.nlm.nih.gov/pubmed/26207314">https://www.ncbi.nlm.nih.gov/pubmed/26207314</a> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://www.tandfonline.com/doi/full/10.3109/03630269.2015.1065419">http://www.tandfonline.com/doi/full/10.3109/03630269.2015.1065419</a> |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection code | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Staff publications for NMDX | Ferriman information and Library Service (North Middlesex) | Ferriman information and Library Service (North Middlesex) | Shelves | 07/06/2022 | 07/06/2022 | 07/06/2022 | Book |