ASPRE trial: performance of screening for preterm pre-eclampsia (Record no. 76322)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03185cam a2200157 4500 |
| 001 - CONTROL NUMBER | |
| control field | NMDX7419 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 120401t2017 xxu||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Janga, D. |
| 240 ## - UNIFORM TITLE | |
| Uniform title | <a href="Ultrasound in Obstetrics & Gynecology">Ultrasound in Obstetrics & Gynecology</a> |
| 245 ## - TITLE STATEMENT | |
| Title | ASPRE trial: performance of screening for preterm pre-eclampsia |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc. | 2017 |
| 500 ## - GENERAL NOTE | |
| General note | NMUH Staff Publications |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | <h4><span style="font-size: 10pt;">OBJECTIVE: </span><span style="font-size: 10pt;"><span style="font-weight: normal;">To examine the performance of screening for preterm and term pre-eclampsia (PE) in the study population participating in the ASPRE (Combined Multimarker Screening and Randomized Patient Treatment with Aspirin for Evidence-Based Preeclampsia Prevention) trial.</span></span></h4><h4><span style="font-size: 10pt;">METHODS: </span><span style="font-size: 10pt;"><span style="font-weight: normal;">This was a prospective first-trimester multicenter study on screening for preterm PE in 26 941 singleton pregnancies by means of an algorithm that combines maternal factors, mean arterial pressure, uterine artery pulsatility index and maternal serum pregnancy-associated plasma protein-A and placental growth factor at 11-13 weeks' gestation. Eligible women with an estimated risk for preterm PE of &gt; 1 in 100 were invited to participate in a double-blind trial of aspirin (150 mg per day) vs placebo from 11-14 weeks until 36 weeks' gestation. In the aspirin group, the incidence of preterm PE was reduced by 62%. In the screened population, the detection rates (DR) and false-positive rates (FPR) for delivery with PE &lt; 37 and ≥ 37 weeks were estimated after adjustment for the effect of aspirin in those receiving this treatment. We excluded 1144 (4.2%) pregnancies because of loss to follow-up or study withdrawal (n = 716), miscarriage (n = 243) or termination (n = 185).</span></span></h4><h4><span style="font-size: 10pt;">RESULTS: </span><span style="font-size: 10pt;"><span style="font-weight: normal;">The study population of 25 797 pregnancies included 180 (0.7%) cases of preterm PE, 450 (1.7%) of term PE and 25 167 (97.6%) without PE. In combined first-trimester screening for preterm PE with a risk cut-off of 1 in 100, the DR was 76.7% (138/180) for preterm PE and 43.1% (194/450) for term PE, at screen-positive rate of 10.5% (2707/25 797) and FPR of 9.2% (2375/25 797).</span></span></h4><h4><span style="font-size: 10pt;">CONCLUSION: </span><span style="font-size: 10pt;"><span style="font-weight: normal;">The performance of screening in the ASPRE study was comparable with that of a study of approximately 60 000 singleton pregnancies used for development of the algorithm; in that study, combined screening detected 76.6% of cases of preterm PE and 38.3% of term PE at a FPR of 10%.</span></span></h4> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://www.ncbi.nlm.nih.gov/pubmed/28741785">https://www.ncbi.nlm.nih.gov/pubmed/28741785</a> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://onlinelibrary.wiley.com/doi/10.1002/uog.18816/epdf">http://onlinelibrary.wiley.com/doi/10.1002/uog.18816/epdf</a> |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection code | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Staff publications for NMDX | Ferriman information and Library Service (North Middlesex) | Ferriman information and Library Service (North Middlesex) | Shelves | 07/06/2022 | 07/06/2022 | 07/06/2022 | Book |