Ultrasonography-detected subclinical inflammation in patients with hand osteoarthritis and established rheumatoid arthritis: evaluation of different ultrasound hand joint scores (Record no. 76411)
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| fixed length control field | 03336cam a2200169 4500 |
| 001 - CONTROL NUMBER | |
| control field | NMDX7560 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 120401t2016 xxu||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Gill, A. |
| 240 ## - UNIFORM TITLE | |
| Uniform title | <a href="Annals of the Rheumatic Diseases">Annals of the Rheumatic Diseases</a> |
| 245 ## - TITLE STATEMENT | |
| Title | Ultrasonography-detected subclinical inflammation in patients with hand osteoarthritis and established rheumatoid arthritis: evaluation of different ultrasound hand joint scores |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc. | 2016 |
| 500 ## - GENERAL NOTE | |
| General note | NMUH Staff Publications |
| 500 ## - GENERAL NOTE | |
| General note | EMBASE |
| 500 ## - GENERAL NOTE | |
| General note | 75 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | <span style="font-size: 10pt;">Background: Despite the interest in validating ultrasound (US) as an outcome measure in rheumatology, progress has been achieved only in defining the pathological US abnormalities associated with rheumatoid arthritis (RA). A recent review of US studies in osteoarthritis (OA) showed very limited data about hand OA (1). Patients with OA have been previously described as having synovial thickening (SH), erosions, osteophytes and rarely positive Power Doppler (PD) signal on US examination (2). These findings suggest a possible overlap between US features of hand OA and RA. Objectives: This study aimed to investigate the usefulness of a standardised US examination protocol for hand joints in differentiating subclinical RA from OA, in patients with equivocal clinical examination. In addition, we explored which simplified hand US scores perform better for every disease taken separately. Methods: A retrospective, observational study was conducted in patients with inflammatory hand joint pains referred to the US clinic with suspected subclinical inflammation. We compared patients with established RA (n=224) and hand OA (n=73), with respect of several demographic, clinical, laboratory and US parameters. We used a 22 hand joint US examination protocol (wrists, metacarpophalangeal and proximal interphalangeal joints bilaterally - OMERACT scoring system) for all patients, and compared it with a range of smaller, pre-defined US joint scores. Results: Significant statistical differences were found for age at the time of scan, US parameters and clinical examination between the two groups. Subclinical joint inflammation in the context of equivocal clinical examination was found in 9.6% OA patients compared to 46.4% in RA (p&lt;0.05). The comparison between several joint scores in OA patients suggested that for detecting subclinical inflammation, multiple finger joints should be examined (20 joint score, comprising MCPs and PIPs was significantly more informative than the 12, 10 and 4 joint scores, (p&lt;0.05)), whereas in RA, the 4 joint scores (assessing wrists and MCP 5 or MCP 2 and 3 bilaterally) detected inflammation just as well as the 22 joint score (p&lt;0.05). Conclusions: Our study findings reflected differences between the incidence and characteristics of subclinical inflammation in patients with RA and OA. The attractiveness of using US scores assessing a smaller number of joints may pose limitations, despite being of benefit in a time-constrained clinical setting. Our study assessed comparatively the utility of several US hand scores, however, further research is need to validate their use in practice.&nbsp;[Conference Abstract]</span> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://ard.bmj.com/content/annrheumdis/75/Suppl_2/1235.2.full.pdf">http://ard.bmj.com/content/annrheumdis/75/Suppl_2/1235.2.full.pdf</a> |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection code | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Date last seen | Price effective from | Koha item type |
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| Staff publications for NMDX | Ferriman information and Library Service (North Middlesex) | Ferriman information and Library Service (North Middlesex) | Shelves | 07/06/2022 | 07/06/2022 | 07/06/2022 | Book |