Methotrexate in the treatment of arthritis (Record no. 76521)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01551cam a2200157 4500 |
| 001 - CONTROL NUMBER | |
| control field | NMDX7687 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 120401t2014 xxu||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Palmer, D. |
| 240 ## - UNIFORM TITLE | |
| Uniform title | <a href="Nursing & Residential Care">Nursing & Residential Care</a> |
| 245 ## - TITLE STATEMENT | |
| Title | Methotrexate in the treatment of arthritis |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc. | 2014 |
| 500 ## - GENERAL NOTE | |
| General note | NMUH Staff Publications |
| 500 ## - GENERAL NOTE | |
| General note | 16 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | <span style="font-size: 10pt;">Methotrexate (MTX) is considered the cornerstone in the treatment of inflammatory arthritis, which affects many people living in care. Its efficacy was demonstrated in randomised controlled study carried out several years ago, both in adult and juvenile inflammatory arthritis (Lentendre, 1985; Petty et al, 2001). MTX was studied in further controlled trials and was reported to be the most common first line disease-modifying anti-rheumatic drugs (DMARD) treatment according to several treatment guidelines (Luqmani et al, 2009; Smolen, 2010; Singh et al, 2012). MTX exerts its disease modifying effect through inhibition of cell proliferation achieved via inhibition of de novo synthesis of purines and pyrimidine, essential for DNA and RNA synthesis. The anti-inflammatory effects of MTX are mediated by an increase of adenosine release (Kremer and Lee, 1986). Dose adjustment should be considered in older adult patients, especially those suffering from renal impairment.&nbsp;</span> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://go.openathens.net/redirector/nhs?url=http%3A%2F%2Fsearch.ebscohost.com%2Fdirect.asp%3Fdb%3Dc8h%26jid%3D%2522Z11%2522%26scope%3Dsite">https://go.openathens.net/redirector/nhs?url=http%3A%2F%2Fsearch.ebscohost.com%2Fdirect.asp%3Fdb%3Dc8h%26jid%3D%2522Z11%2522%26scope%3Dsite</a> |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection code | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Staff publications for NMDX | Ferriman information and Library Service (North Middlesex) | Ferriman information and Library Service (North Middlesex) | Shelves | 07/06/2022 | 07/06/2022 | 07/06/2022 | Book |