Key components of the delirium syndrome and mortality: greater impact of acute change and disorganised thinking in a prospective cohort study (Record no. 76531)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03464cam a2200169 4500 |
| 001 - CONTROL NUMBER | |
| control field | NMDX7706 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 120401t2018 xxu||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sampson, Elizabeth L |
| 240 ## - UNIFORM TITLE | |
| Uniform title | <a href="BMC Geriatrics">BMC Geriatrics</a> |
| 245 ## - TITLE STATEMENT | |
| Title | Key components of the delirium syndrome and mortality: greater impact of acute change and disorganised thinking in a prospective cohort study |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc. | 2018 |
| 500 ## - GENERAL NOTE | |
| General note | NMUH Staff Publications |
| 500 ## - GENERAL NOTE | |
| General note | 18 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | <h4><span style="font-size: 10pt;">BACKGROUND: <span style="font-size: 10pt;"><span style="font-weight: normal;">Delirium increases the risk of mortality during an acute hospital admission. Full syndromal delirium (FSD) is associated with greatest risk and subsyndromal delirium (SSD) is associated with intermediate risk, compared to patients with no delirium - suggesting a dose-response relationship. It is not clear how individual diagnostic symptoms of delirium influence the association with mortality. Our objectives were to measure the prevalence of FSD and SSD, and assess the effect that FSD, SSD and individual symptoms of delirium (from the Confusion Assessment Method-short version (s-CAM)) have on mortality rates.</span></span></span></h4><h4><span style="font-size: 10pt;">METHODS: <span style="font-size: 10pt;"><span style="font-weight: normal;">Exploratory analysis of a prospective cohort (aged ≥70&nbsp;years) with acute (unplanned) medical admission (4/6/2007-4/11/2007). The outcome was mortality (data censored 6/10/2011). The principal exposures were FSD and SSD compared to no delirium (as measured by the CAM), along with individual delirium symptoms on the CAM. Cox regression was used to estimate the impact FSD and SSD and individual CAM items had on mortality.</span></span></span></h4><h4><span style="font-size: 10pt;">RESULTS: <span style="font-size: 10pt;"><span style="font-weight: normal;">The cohort (n&nbsp;=&nbsp;610) mean age was 83 (SD 7); 59% were female. On admission, 11% had FSD and 33% had SSD. Of the key diagnostic symptoms for delirium, 17% acute onset, 19% inattention, 17% disorganised thinking and 17% altered level of consciousness. Unadjusted analysis found FSD had an increased hazard ratio (HR) of 2.31 (95% CI 1.71, 3.12), for SSD the HR was 1.26 (1.00, 1.59). Adjusted analysis remained significant for FSD (1.55 95% CI 1.10, 2.18) but nonsignificant for SSD (HR&nbsp;=&nbsp;0.92 95% CI 0.70, 1.19). Two CAM items were significantly associated with mortality following adjustment: acute onset and disorganised thinking.</span></span></span></h4><h4><span style="font-size: 10pt;">CONCLUSION: <span style="font-size: 10pt;"><span style="font-weight: normal;">We observed a dose-response relationship between mortality and delirium, FSD had the greatest risk and SSD having intermediate risk. The CAM items "acute-onset" and "disorganised thinking" drove the associations observed. Clinically, this highlights the necessity of identifying individual symptoms of delirium.</span></span></span></h4><span style="font-size: 10pt;">&nbsp;</span> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://www.ncbi.nlm.nih.gov/pubmed/29370764">https://www.ncbi.nlm.nih.gov/pubmed/29370764</a> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://bmcgeriatr.biomedcentral.com/track/pdf/10.1186/s12877-018-0719-1?site=bmcgeriatr.biomedcentral.com">https://bmcgeriatr.biomedcentral.com/track/pdf/10.1186/s12877-018-0719-1?site=bmcgeriatr.biomedcentral.com</a> |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection code | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Staff publications for NMDX | Ferriman information and Library Service (North Middlesex) | Ferriman information and Library Service (North Middlesex) | Shelves | 07/06/2022 | 07/06/2022 | 07/06/2022 | Book |