Liver ultrasound to evaluate patients with HIV and hepatitis B/C co-infection: coverage and findings from the UK CHIC Study (Record no. 76644)
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| 000 -LEADER | |
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| fixed length control field | 03046cam a2200169 4500 |
| 001 - CONTROL NUMBER | |
| control field | NMDX7899 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 120401t2018 xxu||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Schwenk, A. |
| 240 ## - UNIFORM TITLE | |
| Uniform title | <a href="HIV Medicine">HIV Medicine</a> |
| 245 ## - TITLE STATEMENT | |
| Title | Liver ultrasound to evaluate patients with HIV and hepatitis B/C co-infection: coverage and findings from the UK CHIC Study |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc. | 2018 |
| 500 ## - GENERAL NOTE | |
| General note | NMUH Staff Publications |
| 500 ## - GENERAL NOTE | |
| General note | EMBASE |
| 500 ## - GENERAL NOTE | |
| General note | 19 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | <span style="font-size: 10pt;">Background: Liver ultrasonography (US) is frequently used to evaluate HIVpositive patients with abnormal liver function tests (LFTs) or for hepatocellular carcinoma surveillance in selected populations. Coverage rates and findings of liver US in HIV and HBV or HCV coinfected UK cohorts are not known. Methods: HBV or HCV coinfected individuals in the UK CHIC Study were included and followed from latest of: UK CHIC entry, date first known to be HBV or HCV coinfected or 01/01/2004, until last date seen in the dataset. Poisson regression (giving incidence rate ratios (IRR)) assessed rates and predictors of ever having a liver US. Associations between US findings and clinical and demographic factors were examined using logistic regression (giving odds ratios (OR)), with generalised estimating equations to account for repeated measures. Results: 4037 HIV and HBV and/or HCV co-infected individuals were included; 2584 (64%) had HCV and 1596 (39.5%) had HBV infections. 1673 (41%) had 3366 US scans during FU (range 0-16) giving an incidence [95% CI] of 18.3 [17.6, 18.8] US per 100 person-years. Factors associated with undergoing US included HBV coinfection (adjusted IRR [95% CI]=1.2 [1.0, 1.3] vs. HCV), later calendar year (aIRR [95% I]=1.8 [1.5, 2.2] 2009-2011 vs. 2004- 2005), not taking antiretroviral therapy, low CD4 count (aIRR [95% CI]=1.0 [1.0, 1.0] per 50 cells/mm3), detectable viral load (aIRR [95% CI]=0.8 [0.7, 1.0] undetectable viral load vs. detectable), higher ALT (aIRR [95% CI]=1.1 [1.1, 1.1] per 20 U/l) and low serum triglycerides (TGI) (aIRR [95% CI]=0.9 [0.9, 1.0] per mmol/l higher). Of scanned individuals, 18% had steatosis identified and this was observed more frequently in HCV than HBV-infected individuals. Older age (aOR [95% CI]=3.9 [1.7, 9.2] &gt;=50 vs. &lt;30 years), non-black ethnicity, higher ALT (aOR [95% CI]=1.0 (1.0, 1.0) per 20 U/l) and higher TGI (aOR [95% CI]=1.3 [1.2, 1.5] per mmol/l) were independently associated with steatosis. The lowest rate of steatosis was seen in people taking lopinavir when compared to efavirenz (aOR [95% CI]=0.5 [0.3, 0.9]). Conclusion: We observed a low, widely variable rate of liver US in HIV and HBV or HCV coinfected patients that increased over time. US were performed more frequently in those with advanced HIV. Steatosis was identified in 18% of coinfected individuals scanned and was independently associated with ethnicity, age, ALT and TGI.&nbsp;[Conference abstract]</span> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/hiv.12614">https://onlinelibrary.wiley.com/doi/epdf/10.1111/hiv.12614</a> |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection code | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Date last seen | Price effective from | Koha item type |
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| Staff publications for NMDX | Ferriman information and Library Service (North Middlesex) | Ferriman information and Library Service (North Middlesex) | Shelves | 07/06/2022 | 07/06/2022 | 07/06/2022 | Book |