White matter integrity and processing speed in sickle cell anaemia (Record no. 76648)

MARC details
000 -LEADER
fixed length control field 03436cam a2200157 4500
001 - CONTROL NUMBER
control field NMDX7908
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 120401t2018 xxu||||| |||| 00| 0 eng d
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Wilkey, O.B.
240 ## - UNIFORM TITLE
Uniform title <a href="Neurology">Neurology</a>
245 ## - TITLE STATEMENT
Title White matter integrity and processing speed in sickle cell anaemia
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Date of publication, distribution, etc. 2018
500 ## - GENERAL NOTE
General note NMUH Staff Publications
520 ## - SUMMARY, ETC.
Summary, etc. &lt;h4&gt;&lt;span style="font-size: 10pt;"&gt;OBJECTIVE: &lt;span style="font-size: 10pt;"&gt;&lt;span style="font-weight: normal;"&gt;The purpose of this retrospective cross-sectional study was to investigate whether changes in white matter integrity are related to slower processing speed in sickle cell anemia.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/h4&gt;&lt;h4&gt;&lt;span style="font-size: 10pt;"&gt;METHODS: &lt;span style="font-size: 10pt;"&gt;&lt;span style="font-weight: normal;"&gt;Thirty-seven patients with silent cerebral infarction, 46 patients with normal MRI, and 32 sibling controls (age range 8-37 years) underwent cognitive assessment using the Wechsler scales and 3-tesla MRI. Tract-based spatial statistics analyses of diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) parameters were performed.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/h4&gt;&lt;h4&gt;&lt;span style="font-size: 10pt;"&gt;RESULTS: &lt;span style="font-size: 10pt;"&gt;&lt;span style="font-weight: normal;"&gt;Processing speed index (PSI) was lower in patients than controls by 9.34 points (95% confidence interval: 4.635-14.855, &lt;em&gt;p&lt;/em&gt; = 0.0003). Full Scale IQ was lower by 4.14 scaled points (95% confidence interval: -1.066 to 9.551, &lt;em&gt;p&lt;/em&gt; = 0.1), but this difference was abolished when PSI was included as a covariate (&lt;em&gt;p&lt;/em&gt; = 0.18). There were no differences in cognition between patients with and without silent cerebral infarction, and both groups had lower PSI than controls (both &lt;em&gt;p&lt;/em&gt; &amp;lt; 0.001). In patients, arterial oxygen content, socioeconomic status, age, and male sex were identified as predictors of PSI, and correlations were found between PSI and DTI scalars (fractional anisotropy &lt;em&gt;r&lt;/em&gt; = 0.614, &lt;em&gt;p&lt;/em&gt; &amp;lt; 0.00001; &lt;em&gt;r&lt;/em&gt; = -0.457, &lt;em&gt;p&lt;/em&gt; &amp;lt; 0.00001; mean diffusivity &lt;em&gt;r&lt;/em&gt; = -0.341, &lt;em&gt;p&lt;/em&gt; = 0.0016; radial diffusivity &lt;em&gt;r&lt;/em&gt; = -0.457, &lt;em&gt;p&lt;/em&gt; &amp;lt; 0.00001) and NODDI parameters (intracellular volume fraction &lt;em&gt;r&lt;/em&gt; = 0.364, &lt;em&gt;p&lt;/em&gt; = 0.0007) in widespread regions.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/h4&gt;&lt;h4&gt;&lt;span style="font-size: 10pt;"&gt;CONCLUSION: &lt;span style="font-size: 10pt;"&gt;&lt;span style="font-weight: normal;"&gt;Our results extend previous reports of impairment that is independent of presence of infarction and may worsen with age. We identify processing speed as a vulnerable domain, with deficits potentially mediating difficulties across other domains, and provide evidence that reduced processing speed is related to the integrity of normal-appearing white matter using microstructure parameters from DTI and NODDI.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/h4&gt;&amp;nbsp;
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://www.ncbi.nlm.nih.gov/pubmed/29752305">https://www.ncbi.nlm.nih.gov/pubmed/29752305</a>
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://n.neurology.org/content/early/2018/05/11/WNL.0000000000005644.full-text.pdf">http://n.neurology.org/content/early/2018/05/11/WNL.0000000000005644.full-text.pdf</a>
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection code Home library Current library Shelving location Date acquired Total Checkouts Date last seen Price effective from Koha item type
        Staff publications for NMDX Ferriman information and Library Service (North Middlesex) Ferriman information and Library Service (North Middlesex) Shelves 07/06/2022   07/06/2022 07/06/2022 Book
London Health Libraries Koha Consortium privacy notice