MARC details
| 000 -LEADER |
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| fixed length control field |
06240cam a2200805 a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
ocn214281935 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20221128211129.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION |
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| fixed length control field |
m d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr cn||||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
080327s2008 njua obf 001 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
DG1 |
| 016 7# - NATIONAL BIBLIOGRAPHIC AGENCY CONTROL NUMBER |
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| Record control number |
101464682 |
| Source |
DNLM |
| 019 ## - |
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| -- |
179844166 |
| -- |
228416499 |
| -- |
476138555 |
| -- |
505113439 |
| -- |
646743032 |
| -- |
806201426 |
| -- |
815556284 |
| -- |
961621964 |
| -- |
962689282 |
| -- |
965976119 |
| -- |
988501320 |
| -- |
992087967 |
| -- |
1037735454 |
| -- |
1038668017 |
| -- |
1045485710 |
| -- |
1055347529 |
| -- |
1059043471 |
| -- |
1066416415 |
| -- |
1081280772 |
| -- |
1097109031 |
| -- |
1228528549 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
9780470249055 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| ISBN |
0470249056 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| ISBN |
9780470249024 |
| Qualifying information |
(electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| ISBN |
0470249021 |
| Qualifying information |
(electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| ISBN |
1281237418 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| ISBN |
9781281237415 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| Cancelled/invalid ISBN |
9780470248478 |
| Qualifying information |
(cloth) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| Cancelled/invalid ISBN |
0470248475 |
| Qualifying information |
(cloth) |
| 035 ## - SYSTEM CONTROL NUMBER |
|---|
| System control number |
225452 |
| -- |
(N$T) |
| 035 ## - SYSTEM CONTROL NUMBER |
|---|
| System control number |
(OCoLC)214281935 |
| Canceled/invalid control number |
(OCoLC)179844166 |
| -- |
(OCoLC)228416499 |
| -- |
(OCoLC)476138555 |
| -- |
(OCoLC)505113439 |
| -- |
(OCoLC)646743032 |
| -- |
(OCoLC)806201426 |
| -- |
(OCoLC)815556284 |
| -- |
(OCoLC)961621964 |
| -- |
(OCoLC)962689282 |
| -- |
(OCoLC)965976119 |
| -- |
(OCoLC)988501320 |
| -- |
(OCoLC)992087967 |
| -- |
(OCoLC)1037735454 |
| -- |
(OCoLC)1038668017 |
| -- |
(OCoLC)1045485710 |
| -- |
(OCoLC)1055347529 |
| -- |
(OCoLC)1059043471 |
| -- |
(OCoLC)1066416415 |
| -- |
(OCoLC)1081280772 |
| -- |
(OCoLC)1097109031 |
| -- |
(OCoLC)1228528549 |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
|---|
| Classification number |
QV 744 |
| Item number |
P9225 2008 |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
MED |
| Subject category code subdivision |
071000 |
| Source |
bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
MMG |
| Source |
bicssc |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
MAIN |
| 245 00 - TITLE STATEMENT |
|---|
| Title |
Preclinical development handbook. |
| Name of part/section of a work |
ADME and biopharmaceutical properties / |
| Statement of responsibility, etc |
|
| Medium |
[E-Book] |
| 246 30 - VARIANT TITLE |
|---|
| Title |
ADME and biopharmaceutical properties |
| 260 ## - PUBLICATION INFORMATION |
|---|
| Place of publication |
Hoboken, N.J. : |
| Publisher |
Wiley-Interscience, |
| Date |
2008. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Physical description |
1 online resource (xv, 1329 pages) : |
| Other physical details |
illustrations |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 490 1# - SERIES TITLE |
|---|
| Series statement |
Pharmaceutical Development Series |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc |
Includes bibliographical references and index. |
| 520 ## - ABSTRACT |
|---|
| Abstract |
This book gives the professional pharmaceutical scientist a basic and comprehensive tool to facilitate the preclinical development process by bringing together an overview of the preclinical process and a compendium of methods and techniques that need to. |
| 505 0# - CONTENTS |
|---|
| Contents |
PRECLINICAL DEVELOPMENT HANDBOOK ADME and Biopharmaceutical Properties; CONTRIBUTORS; CONTENTS; Preface; 1 Modeling and Informatics in Drug Design; 2 Computer Techniques: Identifying Similarities Between Small Molecules; 3 Protein-Protein Interactions; 4 Method Development for Preclinical Bioanalytical Support; 5 Analytical Chemistry Methods: Developments and Validation; 6 Chemical and Physical Characterizations of Potential New Chemical Entity; 7 Permeability Assessment; 8 How and Where Are Drugs Absorbed?; 9 Absorption of Drugs after Oral Administration |
| 505 8# - CONTENTS |
|---|
| Contents |
10 Distribution: Movement of Drugs through the Body11 The Blood-Brain Barrier and Its Effect on Absorption and Distribution; 12 Transporter Interactions in the ADME Pathway of Drugs; 13 Accumulation of Drugs in Tissues; 14 Salt and Cocrystal Form Selection; 15 Dissolution; 16 Stability: Physical and Chemical; 17 Dosage Formulation; 18 Cytochrome P450 Enzymes; 19 Metabolism Kinetics; 20 Drug Clearance; 21 In Vitro Metabolism in Preclinical Drug Development; 22 Utilization of In Vitro Cytochrome P450 Inhibition Data for Projecting Clinical Drug-Drug Interactions |
| 505 8# - CONTENTS |
|---|
| Contents |
23 In Vivo Metabolism in Preclinical Drug Development24 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Scientific Concepts and Practical Considerations; 25 Mechanisms and Consequences of Drug-Drug Interactions; 26 Species Comparison of Metabolism in Microsomes and Hepatocytes; 27 Metabolite Profiling and Structural Identification; 28 Linkage between Toxicology of Drugs and Metabolism; 29 Allometric Scaling; 30 Interrelationship between Pharmacokinetics and Metabolism; 31 Experimental Design Considerations in Pharmacokinetic Studies; 32 Bioavailability and Bioequivalence Studies |
| 505 8# - CONTENTS |
|---|
| Contents |
33 Mass Balance Studies34 Pharmacodynamics; 35 Physiologically Based Pharmacokinetic Modeling; 36 Mathematical Modeling as a New Approach for Improving the Efficacy/Toxicity Profile of Drugs: The Thrombocytopenia Case Study; 37 Regulatory Requirements for INDs/FIH (First in Human) Studies; 38 Data Analysis; Index |
| 590 ## - LOCAL NOTE (RLIN) |
|---|
| Local note |
WorldCat record variable field(s) change: 650 |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Pharmacokinetics |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Drug development |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Drugs |
| General subdivision |
Design. |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Computer simulation. |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Digital computer simulation. |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Chemical models. |
| 650 12 - SUBJECT HEADINGS |
|---|
| Subject term |
Drug Design |
| 650 22 - SUBJECT HEADINGS |
|---|
| Subject term |
Computational Biology |
| General subdivision |
methods |
| 650 22 - SUBJECT HEADINGS |
|---|
| Subject term |
Computer Simulation |
| 650 22 - SUBJECT HEADINGS |
|---|
| Subject term |
Models, Chemical |
| 650 22 - SUBJECT HEADINGS |
|---|
| Subject term |
Pharmaceutical Preparations |
| General subdivision |
metabolism |
| 700 1# - ADDED PERSONAL NAME |
|---|
| Added personal author |
Gad, Shayne C., |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| Uniform title |
Pharmaceutical Development Series. |
| 856 40 - ONLINE RESOURCE |
|---|
| Uniform Resource Identifier |
<a href="https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=225452">https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=225452</a> |
| Link text |
Kingston Hospital NHS Foundation Trust OpenAthens account holders click here for access |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Suppress in OPAC |
Do not Suppress in OPAC |
| 588 0# - SOURCE OF DESCRIPTION NOTE |
|---|
| Source of description note |
Print version record. |
| 938 ## - |
|---|
| -- |
Baker and Taylor |
| -- |
BTCP |
| -- |
BK0007504472 |
| 938 ## - |
|---|
| -- |
EBL - Ebook Library |
| -- |
EBLB |
| -- |
EBL333797 |
| 938 ## - |
|---|
| -- |
ebrary |
| -- |
EBRY |
| -- |
ebr10226748 |
| 938 ## - |
|---|
| -- |
EBSCOhost |
| -- |
EBSC |
| -- |
225452 |
| 938 ## - |
|---|
| -- |
ProQuest MyiLibrary Digital eBook Collection |
| -- |
IDEB |
| -- |
123741 |
| 938 ## - |
|---|
| -- |
YBP Library Services |
| -- |
YANK |
| -- |
2940099 |
| 938 ## - |
|---|
| -- |
YBP Library Services |
| -- |
YANK |
| -- |
2796393 |
| 994 ## - |
|---|
| -- |
92 |
| -- |
N$T |