MARC details
| 000 -LEADER |
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| fixed length control field |
05213cam a2200637Ia 4500 |
| 001 - CONTROL NUMBER |
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| control field |
ocn299152535 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20221128211137.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION |
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| fixed length control field |
m d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr cnu---unuuu |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
090123s2008 nyuaf ob 001 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
N$T |
| 016 7# - NATIONAL BIBLIOGRAPHIC AGENCY CONTROL NUMBER |
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| Record control number |
014101299 |
| Source |
Uk |
| 016 7# - NATIONAL BIBLIOGRAPHIC AGENCY CONTROL NUMBER |
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| Record control number |
017596573 |
| Source |
Uk |
| 019 ## - |
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| -- |
842267696 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
9780080554952 |
| Qualifying information |
(electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
0080554954 |
| Qualifying information |
(electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
9780123694485 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
0123694485 |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
239287 |
| -- |
(N$T) |
| 035 ## - SYSTEM CONTROL NUMBER |
|---|
| System control number |
(OCoLC)299152535 |
| Canceled/invalid control number |
(OCoLC)842267696 |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
|---|
| Classification number |
2008 A-287 |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
|---|
| Classification number |
QV 269 |
| Item number |
N397c 2008 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED |
| Subject category code subdivision |
062000 |
| Source |
bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
HEA |
| Subject category code subdivision |
039030 |
| Source |
bisacsh |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
MAIN |
| 245 00 - TITLE STATEMENT |
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| Title |
Cancer drug design and discovery |
| Statement of responsibility, etc |
|
| Medium |
[E-Book] |
| 250 ## - EDITION |
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| Edition statement |
1st ed. |
| 260 ## - PUBLICATION INFORMATION |
|---|
| Place of publication |
New York : |
| Publisher |
Academic Press, |
| Date |
2008. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Physical description |
1 online resource (xv, 473 pages, 27 unnumbered pages of plates) : |
| Other physical details |
illustrations (some color) |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc |
Includes bibliographical references and index. |
| 505 0# - CONTENTS |
|---|
| Contents |
Modern cancer drug discovery : integrating targets, technologies and treatments / Paul Workman and Ian Collins -- Preclinical pharmacology and in vivo models / Lloyd Kelland -- Clinical trial designs for more rapid proof-of-principle and approval / Mitesh J. Borad and Daniel D. Van Hoff -- Structural biology and anticancer drug design / Dominic Tisi [and others] -- Natural product chemistry and anticancer drug discovery / Donna M. Huryn and Peter Wipf -- Pharmacokinetics and ADME optimization in drug discovery / Chad L. Stoner, Matthew D. Troutman and Caroline E. Laverty -- Temozolomide : from cytotoxic to molecularly-targeted agent / Malcolm F.G. Stevens -- Camptothecins for drug design, cancer cell death and gene targeting / J�er�ome Kluza [and others] -- Targeting thymidylate synthase by antifolate drugs for the treatment of cancer / Ann L. Jackman, Martin Forster and Matthew Ng -- Targeting inactive kinases : structure as a foundation for cancer drug discovery / David J. Hosfield and Clifford D. Mol -- Cell cycle inhibitors in cancer : current status and future directions / Peter M. Fischer -- Inhibition of DNA repair as a therapeutic target / Nicola J. Curtin and Thomas Helleday -- HSP90 inhibitors : targeting the cancer chaperone for combinatorial blockade of oncogenic pathways / Swee Y. Sharp, Keith Jones and Paul Workman -- Heat shock protein-90 directed therapeutics and target validation / Edward A. Sausville -- Inhibitors of tumor angiogenesis / Adrian L. Harris and Daniele G. Generali -- The biology and oncology of RAF-ERK signaling / Victoria Emuss and Richard Marais -- Cancer drug resistance / V. Karavasilis [and others] -- Failure modes in anticancer drug discovery and development / Homer L. Pearce, Kerry L. Blanchard and Christopher A. Slapak. |
| 520 ## - ABSTRACT |
|---|
| Abstract |
The ultimate source of information on the design of new anticancer agents, emphasising small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumours. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry, and clinicians taking oncology options. * Covers both currently available drugs as well as those under development * Provides a clinical perspective on trials of new anticancer agents * Presents drug discovery examples through the use of case histories. |
| 590 ## - LOCAL NOTE (RLIN) |
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| Local note |
WorldCat record variable field(s) change: 650 |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Antineoplastic agents |
| General subdivision |
Development. |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Antineoplastic agents |
| General subdivision |
Design. |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Cancer |
| General subdivision |
Chemotherapy. |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Antimitotic agents. |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Antineoplastic agents. |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Drugs |
| General subdivision |
Design. |
| 650 12 - SUBJECT HEADINGS |
|---|
| Subject term |
Antineoplastic Agents |
| 650 22 - SUBJECT HEADINGS |
|---|
| Subject term |
Drug Design |
| 650 22 - SUBJECT HEADINGS |
|---|
| Subject term |
Neoplasms |
| General subdivision |
drug therapy |
| 650 #2 - SUBJECT HEADINGS |
|---|
| Subject term |
Antimitotic Agents |
| 700 1# - ADDED PERSONAL NAME |
|---|
| Added personal author |
Neidle, Stephen. |
| 856 40 - ONLINE RESOURCE |
|---|
| Uniform Resource Identifier |
<a href="https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=239287">https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=239287</a> |
| Link text |
Kingston Hospital NHS Foundation Trust OpenAthens account holders click here for access |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Suppress in OPAC |
Do not Suppress in OPAC |
| 588 0# - SOURCE OF DESCRIPTION NOTE |
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| Source of description note |
Print version record. |
| 938 ## - |
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| -- |
EBSCOhost |
| -- |
EBSC |
| -- |
239287 |
| 938 ## - |
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| -- |
YBP Library Services |
| -- |
YANK |
| -- |
2947837 |
| 994 ## - |
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| -- |
92 |
| -- |
N$T |