MARC details
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06209cam a2200781Mu 4500 |
| 001 - CONTROL NUMBER |
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ocn796384275 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20221128211844.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION |
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m d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr |n||||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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120625s2012 gw ob 001 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EBLCP |
| 019 ## - |
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| -- |
805654668 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
9783110279351 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
3110279355 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
9783110279344 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
3110279347 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| Cancelled/invalid ISBN |
9783110278996 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| Cancelled/invalid ISBN |
3110278995 |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
(OCoLC)796384275 |
| Canceled/invalid control number |
(OCoLC)805654668 |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
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| Classification number |
2012 F-294 |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
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| Classification number |
WI 703 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
QP |
| Source |
lcco |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED |
| Subject category code subdivision |
060000 |
| Source |
bisacsh |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
MAIN |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal author |
Keitel, Verena. |
| 245 10 - TITLE STATEMENT |
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| Title |
Hepatobiliary Transport in Health and Disease |
| Medium |
[electronic resource]. |
| 260 ## - PUBLICATION INFORMATION |
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| Place of publication |
Berlin : |
| Publisher |
De Gruyter, |
| Date |
2012. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Physical description |
1 online resource (312 pages) |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 505 0# - CONTENTS |
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| Contents |
Preface; List of Contributors; Abbreviations; 1 Physiology of bile formation: Hepatocellular bile salt transporters; 1.1 Introduction; 1.2 Sodium-dependent bile salt uptake into hepatocytes; 1.3 Sodium-independent bile salt uptake into hepatocytes; 1.4 Bile salt export across the canalicular membrane; 1.5 Bile salt salvage systems; 1.6 Concluding remarks; 1.7 References; 2 Structure and function of hepatic ABC transporters; 2.1 Introduction to human ABC transporters expressed in the liver; 2.2 Structure and function of the bile salt export pump (ABCB11; BSEP). |
| 505 8# - CONTENTS |
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| Contents |
2.3 Structure and function of the multidrug resistance protein 3 (ABCB4 MDR3); 2.4 Structure and function of the breast cancer resistance protein (ABCG2; BCRP); 2.5 Concluding remarks; 2.6 References; 3 Short- and long-term regulation of hepatobiliary transport; 3.1 Introduction; 3.2 Short-term regulation of sinusoidal transport systems; 3.3 Long-term regulation of sinusoidal transport systems; 3.4 Short-term regulation of canalicular secretion; 3.5 Long-term regulation of canalicular transport systems; 3.6 Methods of studying subcellular transporter distribution; 3.7 Summary; 3.8 References. |
| 505 8# - CONTENTS |
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| Contents |
4 Nuclear bile acid receptor FXR and hepatobiliary transport systems4.1 Introduction; 4.2 Nuclear receptors; 4.3 Bile acids and the enterohepatic circulation; 4.4 Bile acid homeostasis, enterohepatic circulation, and FXR; 4.5 The role of FXR in the pathogenesis of biliary diseases; 4.6 Concluding remarks; 4.7 References; 5 Bile acid signaling in the liver and the biliary tree; 5.1 Introduction; 5.2 Bile acid signaling in liver parenchymal cells (hepatocytes); 5.3 Bile acid signaling in sinusoidal endothelial cells; 5.4 Bile acid signaling in Kupffer cells. |
| 505 8# - CONTENTS |
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| Contents |
5.5 Bile acid signaling in hepatic stellate cells5.6 Bile acid signaling in the biliary tree; 5.7 References; 6 Modulation of innate immunity and inflammation by bile acids and their receptors; 6.1 Introduction; 6.2 Impact of FXR deletion on immunity and inflammation -- lessons from FXR knockout mice; 6.3 Role of TGR5 in the modulation of immune function; 6.4 Effects of bile acids on immunological function independently of bile acid receptors; 6.5 Obstructive jaundice and its impact on immune function; 6.6 Role of bile acids and FXR in viral infections; 6.7 Concluding remarks; 6.8 References. |
| 505 8# - CONTENTS |
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| Contents |
7 Bile acids as extrahepatic and interorgan signaling molecules7.1 Introduction; 7.2 Bile acid-dependent modulation of glucose homeostasis; 7.3 Impact of bile acids on energy expenditure; 7.4 Bile acid receptors and immune response; 7.5 Role of bile acid receptors in the cardiovascular system; 7.6 Role of bile acid receptors in the kidney; 7.7 Bile acid receptors in the central and peripheral nervous system; 7.8 Summary and future perspectives; 7.9 References; 8 Disorders of bile duct development; 8.1 Introduction. |
| 500 ## - GENERAL NOTE |
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| General note |
8.2 Morphogenesis of the intrahepatic bile duct epithelium: molecular players involved and their relationship with arterial morphogenesis. |
| 520 ## - ABSTRACT |
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| Abstract |
The transport systems involved in hepatobiliary transport have been cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. This book provides surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease. The book will be of interest for biochemists, structural chemists, biologists and clinicians. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes bibliographical references and index. |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Liver |
| General subdivision |
Metabolism. |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Biliary tract |
| General subdivision |
Metabolism. |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Biological transport. |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Liver |
| General subdivision |
Metabolism |
| -- |
Disorders. |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Biliary tract |
| General subdivision |
Metabolism |
| -- |
Disorders. |
| 650 #2 - SUBJECT HEADINGS |
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| Subject term |
Liver |
| General subdivision |
metabolism. |
| 650 #2 - SUBJECT HEADINGS |
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| Subject term |
Bile Acids and Salts |
| General subdivision |
metabolism. |
| 650 #2 - SUBJECT HEADINGS |
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| Subject term |
Biological Transport. |
| 650 #2 - SUBJECT HEADINGS |
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| Subject term |
Organic Anion Transporters, Sodium-Dependent. |
| 650 #2 - SUBJECT HEADINGS |
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| Subject term |
Organic Anion Transporters, Sodium-Independent. |
| 650 #4 - SUBJECT HEADINGS |
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| Subject term |
Bile Acids and Salts |
| General subdivision |
metabolism. |
| 650 #4 - SUBJECT HEADINGS |
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| Subject term |
Biological Transport. |
| 650 #4 - SUBJECT HEADINGS |
|---|
| Subject term |
Liver |
| General subdivision |
metabolism. |
| 650 #4 - SUBJECT HEADINGS |
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| Subject term |
Organic Anion Transporters, Sodium-Dependent. |
| 650 #4 - SUBJECT HEADINGS |
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| Subject term |
Organic Anion Transporters, Sodium-Independent. |
| 700 1# - ADDED PERSONAL NAME |
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| Added personal author |
Kubitz, Ralf. |
| 700 1# - ADDED PERSONAL NAME |
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| Added personal author |
H�aussinger, Dieter. |
| 856 40 - ONLINE RESOURCE |
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| Uniform Resource Identifier |
<a href="https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=471030">https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=471030</a> |
| Link text |
Kingston Hospital NHS Foundation Trust OpenAthens account holders click here for access |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Suppress in OPAC |
Do not Suppress in OPAC |
| 588 0# - SOURCE OF DESCRIPTION NOTE |
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| Source of description note |
Print version record. |
| 938 ## - |
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Coutts Information Services |
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COUT |
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24364371 |
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182.00 USD |
| 938 ## - |
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EBL - Ebook Library |
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EBLB |
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EBL893693 |
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ebrary |
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EBRY |
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ebr10582267 |
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EBSCOhost |
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EBSC |
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471030 |
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Ingram Digital eBook Collection |
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IDEB |
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417050 |
| 938 ## - |
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YBP Library Services |
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YANK |
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7624854 |
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92 |
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N$T |