MARC details
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06465cam a2200721Ma 4500 |
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ocn894609030 |
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OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20221128212310.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION |
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m d |
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cr ||||||||||| |
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141021s2014 ne ob 001 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UKMGB |
| 016 7# - NATIONAL BIBLIOGRAPHIC AGENCY CONTROL NUMBER |
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| Record control number |
016933102 |
| Source |
Uk |
| 016 7# - NATIONAL BIBLIOGRAPHIC AGENCY CONTROL NUMBER |
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| Record control number |
016931176 |
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Uk |
| 019 ## - |
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894171500 |
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911047828 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
9780124105492 |
| Qualifying information |
(PDF ebook) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
0124105491 |
| Qualifying information |
(PDF ebook) |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
593413 |
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(N$T) |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
(OCoLC)894609030 |
| Canceled/invalid control number |
(OCoLC)894171500 |
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(OCoLC)911047828 |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
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| Classification number |
WL 140 |
| Item number |
M7178r 2015 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
HEA |
| Subject category code subdivision |
039000 |
| Source |
bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED |
| Subject category code subdivision |
014000 |
| Source |
bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED |
| Subject category code subdivision |
022000 |
| Source |
bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED |
| Subject category code subdivision |
112000 |
| Source |
bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED |
| Subject category code subdivision |
045000 |
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bisacsh |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
MAIN |
| 130 0# - MAIN ENTRY--UNIFORM TITLE |
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| Uniform title |
Molecular and genetic basis of neurological and psychiatric disease. |
| 245 10 - TITLE STATEMENT |
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| Title |
Rosenberg's molecular and genetic basis of neurological and psychiatric disease |
| Statement of responsibility, etc |
|
| Medium |
[E-Book] |
| 250 ## - EDITION |
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| Edition statement |
Fifth edition. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
Amsterdam : |
| Name of producer, publisher, distributor, manufacturer |
Academic Press, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2014. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Physical description |
1 online resource |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
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rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 500 ## - GENERAL NOTE |
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| General note |
Preceded by Molecular and genetic basis of neurologic and psychiatric disease / editors, Roger N. Rosenberg [and others]. 4th ed. c2008. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes bibliographical references and index. |
| 505 0# - CONTENTS |
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| Contents |
Front Cover; Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease; Copyright; Dedications; Contents; Preface to the Fifth Edition; Contributors; Section I: General Concepts and Tools; Chapter 1: Mendelian, Non-Mendelian, Multigenic Inheritance, and Epigenetics; Introduction; Mendelian traits; Mendel's Laws; Chromosomes and Genes; Mendelian Inheritance; Molecular Pathomechanisms of Mutations; Factors That Modify Classic Mendelian Inheritance Patterns; New Mutations, Mosaicism, and Somatic Mutations; Penetrance and Expressivity; Repeat expansion disorders. |
| 505 8# - CONTENTS |
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| Contents |
Non-mendelian inheritanceMitochondrial Inheritance; Imprinting; Uniparental Disomy; Imprinting, UPD, and Genetic Disorders; Chromosomal and genomic disorders; Aneuploidy; lsochromosomes; Translocations; Intrachromosomal Rearrangements; Mechanisms for Formation of Chromosomal Rearrangements; Nonallelic homologous recombination (NAHR); Nonhomologous end joining (NHEJ); Fork stalling and template switching/microhomology-mediated break-induced replication (FoSTeS/MMBIR); How Chromosomal Rearrangements Confer Phenotypes; Assays for Chromosomal and Genomic Disorders; Multigenic inheritance. |
| 505 8# - CONTENTS |
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| Contents |
Digenic InheritanceModifier Genes; Complex traits; Genetic Features of Complex Traits; Assessing Variation in the Human Genome; Genetic Variation and Complex Traits; Examples of Susceptibility Genes for Complex Traits; Epigenetics; DNA Methylation and Hydroxymethylation; Histone Modifications and Higher Order Chromatin Remodeling; Noncoding RNA Regulation; The human genome: High-throughput technologies; Conclusions; References; Chapter 2: Genotype-Phenotype Correlations; Introduction; Single phenotype: Multiple genes; Single gene: Multiple phenotypes; Neuronal/cellular selective vulnerability. |
| 505 8# - CONTENTS |
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| Contents |
Highly variable systemic phenotypesPenetrance and age of onset; Conclusion and future directions; References; Chapter 3: Immunogenetics of Neurological Disease; Introduction; Epidemiological evidence for genetic susceptibility; Genetics of MS: Family-based investigations; The role of major histocompatibility complex genes; Other immune-related genes; The environment and immune-related genes; Conclusion; References; Chapter 4: Pharmacogenomic Approaches to the Treatment of Sporadic Alzheimer Disease using Cholinomimetic Agents; Introduction; Genetic risk factors and sporadic alzheimer disease. |
| 505 8# - CONTENTS |
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| Contents |
Genetic risk factors, cholinergic dysfunction, and alzheimer diseaseApoE4 and cholinomimetic drugs in alzheimer disease; Experimental drugs and their relationship to the apoE4 allele; Acetylcholinesterase and butyrylcholinesterase genetic variants in dementia; Acknowledgements; References; Chapter 5: Application of Mouse Genetics to Human Disease: Generation and Analysis of Mouse Models; Generation and Analysis of Mouse Models; Introduction; Creating mouse models; Transgenesis; Gene Targeting; Random Mutagenesis; Phenotypic analysis of mouse models; Summary; References. |
| 520 ## - ABSTRACT |
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| Abstract |
" ... With this new edition the three key markets, research scientists, clinicians, and genetic counselors will all continue to benefit from the content. The research community will find great value in the coverage of genomics, animal models, and diagnostic methods along with a a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations. And genetic counselors will find this a comprehensive tutorial reference on the latest advances in the science, with links to genetic testing for specific diseases. |
| 590 ## - LOCAL NOTE (RLIN) |
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| Local note |
WorldCat record variable field(s) change: 650 |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Nervous system |
| General subdivision |
Diseases |
| -- |
Molecular aspects. |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Nervous system |
| General subdivision |
Diseases |
| -- |
Genetic aspects. |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Molecular neurobiology. |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Neurogenetics. |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Genetic disorders. |
| 650 12 - SUBJECT HEADINGS |
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| Subject term |
Nervous System Diseases |
| General subdivision |
genetics |
| 650 22 - SUBJECT HEADINGS |
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| Subject term |
Mental Disorders |
| General subdivision |
genetics |
| 650 22 - SUBJECT HEADINGS |
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| Subject term |
Genetic Diseases, Inborn |
| 700 1# - ADDED PERSONAL NAME |
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| Added personal author |
Rosenberg, Roger N., |
| Relator term |
editor. |
| 700 1# - ADDED PERSONAL NAME |
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| Added personal author |
Pascual, Juan M., |
| Relator term |
editor. |
| 856 40 - ONLINE RESOURCE |
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| Uniform Resource Identifier |
<a href="https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=593413">https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=593413</a> |
| Link text |
Kingston Hospital NHS Foundation Trust OpenAthens account holders click here for access |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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Do not Suppress in OPAC |
| 588 0# - SOURCE OF DESCRIPTION NOTE |
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| Source of description note |
CIP data; item not viewed. |
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EBL - Ebook Library |
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EBLB |
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EBL1826802 |
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EBSCOhost |
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EBSC |
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593413 |
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ProQuest MyiLibrary Digital eBook Collection |
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IDEB |
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cis30008414 |
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92 |
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N$T |