MARC details
| 000 -LEADER |
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04927cam a2200589 i 4500 |
| 001 - CONTROL NUMBER |
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ocn960447053 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20221128212335.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION |
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m d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr ||||||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
130408s2013 nyua ob 001 0 eng |
| 010 ## - LIBRARY OF CONGRESS CONTROL NUMBER |
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| LC control number |
2019713811 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
DLC |
| 019 ## - |
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| -- |
854768436 |
| -- |
923670027 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
9781626187979 |
| Qualifying information |
ebook |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| ISBN |
1626187975 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| Cancelled/invalid ISBN |
1626187479 |
| Qualifying information |
hbk. |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| Cancelled/invalid ISBN |
9781626187474 |
| Qualifying information |
hbk. |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
610688 |
| -- |
(N$T) |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
(OCoLC)960447053 |
| Canceled/invalid control number |
(OCoLC)854768436 |
| -- |
(OCoLC)923670027 |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
pcc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
HEA |
| Subject category code subdivision |
039140 |
| Source |
bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED |
| Subject category code subdivision |
056000 |
| Source |
bisacsh |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
MAIN |
| 245 00 - TITLE STATEMENT |
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| Title |
Drosophila melanogaster models of motor neuron disease |
| Statement of responsibility, etc |
|
| Medium |
[E-Book] |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
New York : |
| Name of producer, publisher, distributor, manufacturer |
Nova Biomedical, |
| Date of production, publication, distribution, manufacture, or copyright notice |
[2013] |
| 300 ## - PHYSICAL DESCRIPTION |
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| Physical description |
1 online resource. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 490 1# - SERIES TITLE |
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| Series statement |
Neurodegenerative diseases-laboratory and clinical research |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes bibliographical references and index. |
| 505 0# - CONTENTS |
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| Contents |
DROSOPHILA MELANOGASTER MODELS OF MOTOR NEURON DISEASE ; DROSOPHILA MELANOGASTER MODELS OF MOTOR NEURON DISEASE ; Library of Congress Cataloging-in-Publication Data ; CONTENTS ; PREFACE ; A RESPONSIBLE CHOICE OF MODEL ORGANISM ; Chapter 1 GENETICS OF MOTOR NEURON DISORDERS: FROM GENE DIVERSITY TO COMMON CELLULAR CONSPIRATORS IN SELECTIVE NEURONAL KILLING ; ABSTRACT ; ABBREVIATIONS ; INTRODUCTION ; 1. AMYOTROPHIC LATERAL SCLEROSIS ; 1.1. Common Pathogenic Mechanisms in ALS ; 1.1.1. Oxidative Stress and Mitochondrial Dysfunction; 1.1.2. Dysregulated Intracellular Membrane Trafficking. |
| 505 8# - CONTENTS |
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| Contents |
1.1.3. Abnormal Axonal Transport and Cytoskeleton 1.1.4. Defective RNA Processing ; 1.1.5. Impaired proteostasis ; 2. HEREDITARY SPASTIC PARAPLEGIA ; 2.1. Common Pathogenic Mechanisms in HSP ; 2.1.1. Oxidative Stress and Mitochondrial Dysfunction ; 2.1.2. Dysregulated Intracellular Membrane Trafficking ; 2.1.3. Abnormal Axonal Transport and Cytoskeleton; 2.1.4. Defective Myelination and Lipid Metabolism; 3. CHARCOT-MARIE-TOOTH DISEASE ; 3.1. Common Pathogenic Mechanisms in CMT2 ; 3.1.1. Oxidative Stress and Mitochondrial Dysfunction ; 3.1.2. Dysregulated Intracellular Membrane Trafficking. |
| 505 8# - CONTENTS |
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| Contents |
3.1.3. Abnormal Axonal Transport and Cytoskeleton 3.1.4. Defective Myelination and Lipid Metabolism ; 3.1.5. Impaired proteostasis ; 5. SPINAL MUSCULAR ATROPHIES AND OTHER MOTOR NEURON DISORDERS ; 5.1. Common Pathogenic Mechanisms in SMA and Other MNDs ; 5.1.1. Dysregulated Intracellular Membrane Trafficking ; 5.1.2. Abnormal Axonal Transport and Cytoskeleton ; 5.1.3. Defective RNA Processing ; 5.1.4. Impaired Proteostasis ; CONCLUSION ; ACKNOWLEDGMENTS ; ABOUT THE AUTHORS ; REFERENCES. |
| 505 8# - CONTENTS |
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| Contents |
Chapter 2 A SECRETED LIGAND FOR GROWTH CONE RECEPTORS, VAP MEDIATES THE CELLULAR PATHOLOGICAL DEFECTS IN ALS ABSTRACT; ABBREVIATIONS ; INTRODUCTION ; STUDIES ON MUTATIONS ASSOCIATED WITH FAMILIAL FORMS OF ALS ENABLE US TO UNDERSTAND THE CORE PATHOLOGY OF ALS ; DOMINANTLY INHERITED MISSENSE MUTATIONS IN VAP ARE ASSOCIATED WITH A FAMILIAL FORM OF ALS ; VAP IS AN ER TRANSMEMBRANE PROTEIN CONTAINING A MSP DOMAIN ; VAP FUNCTIONS IN NOVEL SIGNALLING PATHWAYS ; CLEAVAGE OF VAP RELEASES MSP DOMAIN-CONTAINING FRAGMENTS THAT ARE SECRETED. |
| 505 8# - CONTENTS |
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| Contents |
VAP ACTS AS A LIGAND FOR EPH RECEPTOR AND MEDIATES EPH SIGNALLING VAP MSP MEDIATES ROBO AND LAR RECEPTORS AND FUNCTIONS IN THE MAINTENANCE OF THE MITOCHONDRIA IN MUSCLE ; ALS MUTATION CAUSES TWO DIFFERENT TYPES OF DEFECTS: A FAILURE OF VAP SECRETION (LOSS-OF-FUNCTION) AND ER STRESS (GAIN-OF-FUNCTION) AND ER STRESS (GAIN-OF-FUNCTION OR TOXIC DEFECTS) ; CONCLUSION ; ABOUT THE AUTHORS ; REFERENCES ; Chapter 3 FLIES IN MOTION: WHAT DROSOPHILA CAN TELL US ABOUT AMYOTROPHIC LATERAL SCLEROSIS ; ABSTRACT ; INTRODUCTION ; ALS IN MODEL ORGANISMS: YEAST TO MICE ; Current Hypotheses for ALS. |
| 590 ## - LOCAL NOTE (RLIN) |
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| Local note |
Master record variable field(s) change: 072 - OCLC control number change |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Amyotrophic lateral sclerosis. |
| 9 (RLIN) |
5191 |
| 650 #0 - SUBJECT HEADINGS |
|---|
| Subject term |
Motor neurons |
| General subdivision |
Models. |
| 650 #0 - SUBJECT HEADINGS |
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| Subject term |
Drosophila melanogaster. |
| 700 1# - ADDED PERSONAL NAME |
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| Added personal author |
Cauchi, Ruben J., |
| Relator term |
editor. |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
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| Uniform title |
Neurodegenerative diseases--laboratory and clinical research. |
| 856 40 - ONLINE RESOURCE |
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| Uniform Resource Identifier |
<a href="https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=610688">https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=610688</a> |
| Link text |
Kingston Hospital NHS Foundation Trust OpenAthens account holders click here for access |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Suppress in OPAC |
Do not Suppress in OPAC |
| 588 ## - SOURCE OF DESCRIPTION NOTE |
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| Source of description note |
Description based on print version record. |
| 938 ## - |
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YBP Library Services |
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YANK |
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10868042 |
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EBL - Ebook Library |
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EBLB |
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EBL3022817 |
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ebrary |
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EBRY |
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ebr10735437 |
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EBSCOhost |
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EBSC |
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610688 |
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92 |
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N$T |