Cancer signalling - from molecular biology to targeted therapy

General aspects of signal transduction and cancer therapy; Tumor cell heterogeneity and resistance to targeted therapy; Cell cycle of tumor cells; Cell aging and cell death; Growth factors and receptor tyrosine kinases; The philadelphia chromosome and BCR-ABL1; MAPK signalling; P13K-AKT-mTOR signaling; Hypoxia-inducible factors (HIF); NF-kB Pathways; Wnt signalling; Notch signalling; Hedgehog signalling; TGF Signalling

In their ground–breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells."