Clinical challenges in therapeutic drug monitoring: special populations, physiological conditions and pharmacogenomics

Overview of therapeutic drug monitoring -- Immunoassays and issues with interference in therapeutic drug monitoring -- Application of chromatography combined with mass spectrometry in therapeutic drug monitoring -- Monitoring free drug concentration : clinical usefulness and analytical challenges -- Therapeutic drug monitoring of newer antiepileptic drugs -- Therapeutic drug monitoring of antiretrovirals -- Therapeutic drug monitoring in infants and children -- Therapeutic drug monitoring in pregnancy -- Therapeutic drug monitoring in older people -- Therapeutic drug monitoring in obese patients -- Special issues in therapeutic drug monitoring in patients with uremia, liver disease, and in critically ill patients -- Issues of pharmacogenomics in monitoring warfarin therapy -- Alternative sampling strategies for therapeutic drug monitoring -- Integrating therapeutic drug monitoring in the health care environment : therapeutic drug monitoring and pharmacists.

This guide surveys critical issues in therapeutic drug monitoring for non-toxicologists who want to gain greater insight into the unique requirements of special populations and learn how to avoid drug toxicity within a narrow therapeutic window.