Clinical manual of blood and bone marrow transplantation

text

Title Page ; Copyright Page; Contents; Contributors; Preface; Chapter 1 Donor and graft selection strategy; Introduction; What are the donor options?; What are the graft sources?; Donor options; HLA matching for donor selection; HLA matching of UCB; HLA antibodies; How is DSA tested?; Graft composition; PB graft; BM graft; Why is BM graft is preferred in children with hematologic malignancies?; UCB graft; Which graft type should I use?; Non-HLA factors ; What if more than one HLA-matched donor is available? ; Summary; Abbreviations; Selected reading; Chapter 2 HLA typing and implications

IntroductionHLA nomenclature and tissue typing techniques; Polymorphism; Unrelated donor search and tools for donor search and selection; HLA typing for donor search; The donor search; Classical HLA alleles: Impact of mismatching; Non-classical HLA alleles and matching techniques: Impact on outcomes ; Summary; Selected reading; Chapter 3 Risk-benefit assessment in allogeneic hematopoietic transplant: Factors, scores, and models ; Introduction; What are the factors to consider prior to HCT?; Age; Performance status; Socioeconomic status; Race; Organ function

Models used for risk-benefit measurement Models estimating incidences of NRM; Models estimating relapse risk; Models estimating all-cause mortality ; How to evaluate a patient for fitness for HCT; Guidelines on pretransplantation data gathering; Summary and practice points for eligibility for HCT; Acknowledgments; Conflict of interest; Selected reading; Chapter 4 Donor and recipient pretransplant evaluation; Introduction; Donor infectious evaluation; History; Physical examination; Laboratory testing; Management; Special consideration for potentially unsafe products

Donor non-infectious evaluation History; Physical examination; Laboratory testing; Instrumental investigations; Special consideration for female donors of childâ€bearing age group; Recipient infectious evaluation; History; Physical examination; Laboratory testing; Management; Recipient non-infectious evaluation ; Assessment of disease type and status; Assessment of functional status and comorbidities; Assessment of psychosocial, financial, and caregiver issues; Summary; Selected reading; Chapter 5 Autologous and allogeneic progenitor cell mobilization; Introduction; Autologous mobilization

When to use plerixaforWhat if CD34+ cell mobilization fails?; Some practical aspects of autologous CD34+ cell mobilization; Allogeneic CD34+ cell mobilization; What is the best CD34+ cell mobilization regimen for allogeneic healthy volunteer donors?; What is the optimal PB CD34+ cell dose for allogeneic hematopoietic cell transplantation?; High yield points; Selected reading; Chapter 6 Hematopoietic stem and progenitor cell collection by apheresis: Techniques and tricks ; Introduction; Collection techniques and devices used; Technical/clinical aspects of HPC (A) collections; Vascular access

Remote

Includes bibliographical references and index.