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Dynamics of cancer Incidence, inheritance and evolution

By:

Frank, Steven A

Series: Princeton series in evolutionary biologyPublication details: Princeton Princeton University Press 2007ISBN:

9780691133669

Online resources:

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Summary: The book provides a unique conceptual and historical framework for understanding the causes of cancer and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary levels of analysis. He interprets a wide variety of observations on the age of cancer onset, the genetic and environmental causes of disease, and the organization of tissues with regard to stem cell biology and somatic mutation. Frank uses new quantitative methods to tackle some of the classic problems in cancer biology and aging: how the rate of increase in the incidence of lung cancer declines after individuals quit smoking, the distinction between the dosage of a chemical carcinogen and the time of exposure, and the role of inherited genetic variation in familial patterns of cancer.

Holdings
Item type	Home library	Class number	Status	Date due	Barcode
Book 14-day loan	Ferriman information and Library Service (North Middlesex) Shelves		Available

Monograph

The book provides a unique conceptual and historical framework for understanding the causes of&nbsp;cancer&nbsp;and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary levels of analysis. He interprets a wide variety of observations on the age of&nbsp;cancer&nbsp;onset, the genetic and environmental causes of disease, and the organization of tissues with regard to stem cell biology and somatic mutation. Frank uses new quantitative methods to tackle some of the classic problems in&nbsp;cancer&nbsp;biology and aging: how the rate of increase in the incidence of lung&nbsp;cancer&nbsp;declines after individuals quit smoking, the distinction between the dosage of a chemical carcinogen and the time of exposure, and the role of inherited genetic variation in familial patterns of&nbsp;cancer.

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