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Ocular adnexal lymphomas: a review

By:

Richards, H

Contributor(s):

Publication details: 2017Uniform titles:

Expert Review of Ophthalmology

Online resources:

Summary: Introduction: Lymphoma is the commonest malignancy of the ocular adnexa. Its relatively low incidence and significant heterogeneity pose unique clinical, diagnostic and therapeutic challenges, requiring a multidisciplinary approach to its management. We present an overview of the literature regarding the epidemiological and clinico-pathological features of ocular adnexal lymphoma (OAL), current staging methods and therapeutic approaches. Areas covered: We searched MEDLINE for publications on OALs from 1990 to the present day and conducted a manual search of the reference sections of relevant articles and book chapters. Radiotherapy and chemo-immunotherapy are widely used current treatment options in the most common subtypes of OAL and generally offer excellent long-term outcomes. We discuss the emerging role of anti-microbial therapy in marginal zone lymphoma associated with Chlamydia psittaci, the prevalence of which shows significant geographical variation. Several novel and targeted therapeutic agents have emerged in the setting of relapsed and refractory B-cell non-Hodgkin lymphomas, and are likely to become future treatment options in OALs. Expert commentary: The recognition of new pathways and prognostic molecular markers in lymphomas is also expected to result in better prognostication, novel therapeutic targets and personalised therapies in OAL. It is important that multi-center collaborative approaches are pursued for continued progress in the field.

Holdings
Item type	Home library	Collection	Class number	Status	Date due	Barcode
Book	Ferriman information and Library Service (North Middlesex) Shelves	Staff publications for NMDX		Available

NMUH Staff Publications

EMBASE

Introduction: Lymphoma is the commonest malignancy of the ocular adnexa. Its relatively low incidence and significant heterogeneity pose unique clinical, diagnostic and therapeutic challenges, requiring a multidisciplinary approach to its management. We present an overview of the literature regarding the epidemiological and clinico-pathological features of ocular adnexal lymphoma (OAL), current staging methods and therapeutic approaches. Areas covered: We searched MEDLINE for publications on OALs from 1990 to the present day and conducted a manual search of the reference sections of relevant articles and book chapters. Radiotherapy and chemo-immunotherapy are widely used current treatment options in the most common subtypes of OAL and generally offer excellent long-term outcomes. We discuss the emerging role of anti-microbial therapy in marginal zone lymphoma associated with Chlamydia psittaci, the prevalence of which shows significant geographical variation. Several novel and targeted therapeutic agents have emerged in the setting of relapsed and refractory B-cell non-Hodgkin lymphomas, and are likely to become future treatment options in OALs. Expert commentary: The recognition of new pathways and prognostic molecular markers in lymphomas is also expected to result in better prognostication, novel therapeutic targets and personalised therapies in OAL. It is important that multi-center collaborative approaches are pursued for continued progress in the field.&nbsp;

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