Handbook of clinical biochemistry [E-Book]

Includes bibliographical references and index.

Print version record.

Preface; Acknowledgement; Contents; Chapter 1 Interpretation of Biochemical Tests; Introduction; Diagnosis; Management; Prognosis; Screening; Population screening; Selective screening; Individual screening; Opportunistic screening; Other Uses of Laboratory Tests; Biochemical profiling; Baseline; Collection of Specimens; Identification of Patient Specimens; Interpretation of Laboratory Results; Reference Ranges; Population-based reference ranges; Risk-based reference range; Detection of a Significant Change; Factors Affecting Test Results; Biological Factors (Table 1.2); Age; Sex.

Body compositionEthnicity/race; Time of day; Stress; Posture; Food intake; Drugs; Exercise; Intrinsic biological variation; Analytical Factors; The Diagnostic Value of an Investigation; Cut-off Value; Likelihood Ratios; General Principles; Steady State vs. Transient State; Concentration vs. Amount; Concentration vs. Activity; Urinary Excretion; Further Reading; Summary/Key Points; Chapter 2 Disorders of Fluid Balance; Introduction; Distribution and Composition of Body Fluids; Composition of Extracellular Fluid; Composition of Intracellular Fluid; Distribution of Water between ICF and ECF.

OsmolalityRegulation of Total Body Water; Regulation of ECF Volume; Distribution of Fluid between Plasma and Interstitial Fluid; Disorders of Water Metabolism; Water Depletion; Water Excess; Disorders of ECF Volume; Volume Deficit; Volume Excess; Oedema; Mechanism of oedema; 1. Increased capillary hydrostatic pressure; 2. Decreased plasma oncotic pressure; 3. Increased capillary permeability; 4. Lymphatic obstruction; 5. Renal sodium retention; Pulmonary oedema; Pleural effusion and ascites; Hyponatraemia; Causes; Hypovolaemic hyponatraemia; Hypervolaemic hyponatraemia.

Euvolaemic hyponatraemiaClinical Features of Hyponatraemia; Investigation of Hyponatraemia; Management of Hyponatraemia; Hypernatraemia; Hypernatraemia; Management of Hypernatraemia; Management of Hypernatraemia; Polyuria; Investigation of Polyuria; Further Reading; Summary/Key Points; Chapter 3 Potassium; Introduction; Internal Balance; External Balance; Assessment of Potassium Status; Urinary potassium; Hypokalaemia (Table 3.3); Causes; Transcellular shift; Gastrointestinal losses; Renal losses; Drugs (Table 3.4); Effects of Hypokalaemia and Potassium Depletion (Table 3.5).

Investigation of HypokalaemiaManagement; Hyperkalaemia; Causes (Table 3.6); Effects of Hyperkalaemia; Investigation of Hyperkalaemia; Management; Further Reading; Summary/Key Points; Chapter 4 Disorders of Acid-Base Balance; Introduction; Acid-Base Homeostasis; Transport of Carbon Dioxide and the Role of Haemoglobin (Figure 4.1); Role of Kidney in the Maintenance of Acid-Based Balance; Bicarbonate reabsorption (Figure 4.2); Net hydrogen ion excretion (Figure 4.3); 1. Factors regulating hydrogen ion secretion (Table 4.1); 2. Importance of chloride in hydrogen ion secretion (Figure 4.5).

This book discusses the clinical biochemistry of commonly measured analytes. It gives hard numerical data not only for the distribution and balance of analytes, but also for differential diagnosis and treatment. For each analyte distribution, balance and assessment of status, causes and consequences of abnormal values, investigation and treatment options are presented. Every chapter begins with a brief review of the physiology and biochemistry, followed by descriptions of the changes in diseases and how biochemical tests may help in their diagnosis and management. The principle behind the norm.

WorldCat record variable field(s) change: 650