Liver failure : etiologies, neurological complications and emerging therapies [E-Book]

Includes bibliographical references and index.

Description based on print version record.

LIVER FAILURE: ETIOLOGIES, NEUROLOGICAL COMPLICATIONS AND EMERGING THERAPIES; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Section One; Chapter 1: Hepatic Failure as an Early Complication Following Orthotopic Liver Transplantation; Abstract; Introduction; Primary Complications; Vascular Complications; Immunological Complications; Biliary Complications; Team Experience of Early Post-OLT Complications; Conclusion; References; Chapter 2: Neurological Complications in Liver Transplantation; Abstract; Introduction; Communication Pathways between the Liver and the Brain.

Neurological Complications Associated with Liver TransplantationMajor Neurological Complications after OLT; Immunosuppression Toxicity; Encephalopathy; Seizures; Central Nervous System Infections; Central Pontine Myelinolisis; Cerebrovascular Complications; Neuromuscular Disorders; Minor Neurological Complications after OLT; Differences in Neurological Complications Depend on the Type of Allograft; Neurological Complications in Different Transplant Centers; Conclusion; Acknowledgment; References; Chapter 3: Hepatic Encephalopathy, Cerebral Blood Flow and the Changes in Oxidative Metabolism.

AbstractIntroduction; Liver Failure, Cerebral Blood Flow and Autoregulation; Ammonia and Direct Effects on Cerebral Oxidative Metabolism; Cerebral Amino Acid Transport and Metabolism; Therapeutical Implications and Future Targets; Conclusion; References; Chapter 4: New Insight into the Molecular Roles in the Pathogenesis of HepaticEncephalopathy; Abstract; Introduction; Neurobiology of Liver Failure and Hyperammonemia; Possible Cellular and Molecular Mechanism of HE; Therapeutic Target for Hepatic Encephalopathy; In Vivo and In Vitro Models for Study of Chronic Liver Impairment.

Conclusion and Future DirectionsReferences; Chapter 5: Disordered Central Neural Regulation of the Cardiovascular Systemin Liver Failure; Abstract; Introduction; Brainstem/Hypothalamic Neuronal Activation in Liver Disease; Neural Activation and Portal Hypertension: Chicken or Egg?; Conclusion and Future Perspectives; References; Chapter 6: Hepatic Microcirculation in Chronic Liver Disease; Abstract; References; Chapter 7: Astrocytes and Endothelial Cells Behavior Found in Brain Hippocampus in Prehepatic Portal Hypertensive Rats; Abstract; Introduction; Portal Hypertension; The Hippocampus.

Glial CellsEndothelial Cells; Hepatic Encephalopathy; Material and Methods; Results; Discussion; References; Section Two; Chapter 8: Direct Antiviral Agents for Chronic Viral Hepatitis Treatment; Abstract; Introduction; Direct Antiviral Agents for Chronic B Hepatitis Treatment; New Antiviral Drugs for Chronic Hepatits C Treatment; Conclusion; References; Chapter 9: Emergent Therapies in Acute Liver Failure; Abstract; Introduction; Auxiliary Liver Transplantation (ALT); Extracorporeal Liver Assist Devices; Hepatocyte Transplantation; New Perspectives; Acknowledgments; References.

The recently published article ""The Burden of Liver Disease in Europe: A Review of Available Epidemiological Data"" provides a few figures on the enormous problem that liver disease poses for Europeans. Liver disease is estimated to cause 170,000 deaths annually in Europe, 47,000 of which are attributed to liver cancer; 0.5%-0.7% of the European population is affected by chronic hepatitis B; and prevalence rates of hepatitis C virus (HCV) infection in the last decade in the European population ranged from 0.13 to 3.26%. These HCV-infected populations will develop complications in the years to.

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