Current immunosuppressive therapy in organ transplantation [E-Book]

Includes bibliographical references and index.

Description based on print version record.

CURRENT IMMUNOSUPPRESSIVE THERAPY IN ORGAN TRANSPLANTATION ; CURRENT IMMUNOSUPPRESSIVE THERAPY IN ORGAN TRANSPLANTATION 0; Contents ; Foreword ; Preface; Part I: Immunologic Basis ; Chapter 1 Immunology Principles in Organ Transplantation ; Abstract ; Abbreviations ; Introduction ; The "Anatomy" of the Immune System ; Mononuclear Phagocytes ; Neutrophils ; Natural Killer Cells ; Dendritic Cells ; B Cells ; T Cells ; Platelets ; Lymphoid Tissue ; Innate Immune System ; Complement ; Adaptive Immunity and Allograft Rejection ; Hyperacute Rejection (HAR); Acute Rejection

Acute Antibody Mediated Rejection (AMR) Chronic Rejection ; Human Leucocyte Antigens and Calculating Immunological Risk Prior to Solid Organ Transplantation ; Tolerance and Immune Regulation ; Tregs ; Myeloid Derived Suppressor Cells ; Mixed Chimerism -- A Spectrum from Tolerance to Graft versus Host Disease ; Infection, Malignancy and Monitoring Alloimmunity; Composite Tissue Transplantation; Xenotransplantation ; References ; Chapter 2 Cellular and Humoral Responses in Organ Transplantation; Abstract ; Abbreviations ; Introduction; T Cell Biology in Transplantation

Direct and Indirect Alloantigen Recognition TCR Signal Transduction ; Costimulatory and Inhibitory Signals ; Cytokine Regulation of T Cell Response ; T Cell Response to Allograft ; T Cell-Targeted Therapies for Transplantation ; Tolerance in Transplantation ; Memory T Cells in Transplantation ; B Cell Biology in Transplantation ; B Cells and Antibody Production ; Alloreactive Antibodies; Antibody-Mediated Rejection and Treatments ; Antigen-Presenting B Cells in Transplant Tolerance ; Conclusion ; References

Chapter 3 Historical Remarks of Immunosuppressive Therapy in Organ Transplantation Abstract ; Abbreviations ; Introduction; Azathioprine (1960s -- 1980s); Cyclophosphamide (1960s -- 1980s); Induction Therapies (1960s -- Present) ; Cyclosporine (1980s -- 1990s) ; Tacrolimus, Rapamycin and Mycophenolate Mofetil (1990s - 2010s) ; Tacrolimus (FK506, Prograf) ; Sirolimus and Everolimus ; Mycophenolate Mofetil; Current Mainstay Immunosuppressants ; Replacement of CNIs and Application of Biological Agents (2010s -- Future) ; CNIs Nephrotoxicity; CNIs Replacement with MMF and Sirolimus

Application of Biological Agents Summary ; References; Chapter 4 Animal Models in Immunosuppression ; Abstract ; Abbreviations ; Introduction ; Rodent Models for Immunosuppression; Organ-Specific Rodent Transplant Models; Rodent Models of Rejection ; Large Animal Models ; Common Large Animal Models ; Costimulation Blockade ; Cell Depletion; Tolerance Strategies ; Studies of Toxicity: Cyclosporine as Paradigm ; References ; Chapter 5 Ethical Issues of Immunosuppressive Drugs Use in Organ Transplantation ; Abstract ; Abbreviations ; Introduction ; Basic Ethical Principles in ISD Treatment

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