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Thrombotic thrombocytopenic purpura / [e-book]

By: Contributor(s): Series: Fast facts for patientsPublisher: [Basel?] : Karger, [2022]Copyright date: ©2022Description: 1 online resource (32 pages) : illustrations (colour)ISBN:
  • 9783318070552 (PDF ebook) :
Subject(s): Online resources: Summary: Thrombotic thrombocytopenic purpura (TTP) is a rare disorder of the blood coagulation system. In most cases, a lack of the ADAMTS13 enzyme leads to an accumulation of ultra-large von Willebrand factor molecules in the plasma which, in turn, initiate the formation of microscopic thromboses in small blood vessels. TTP is a medical emergency. Timely diagnosis and urgent and effective management are vital - mortality in those untreated is in the region of 90%. The understanding of TTP pathogenesis has increased markedly in recent decades. It is now known that TTP is acquired (immunemediated) or congenital, and that the most common type - the acquired form - predominantly affects women in their 40s.
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Also issued in print: 2022.

Includes bibliographical references and index.

Thrombotic thrombocytopenic purpura (TTP) is a rare disorder of the blood coagulation system. In most cases, a lack of the ADAMTS13 enzyme leads to an accumulation of ultra-large von Willebrand factor molecules in the plasma which, in turn, initiate the formation of microscopic thromboses in small blood vessels. TTP is a medical emergency. Timely diagnosis and urgent and effective management are vital - mortality in those untreated is in the region of 90%. The understanding of TTP pathogenesis has increased markedly in recent decades. It is now known that TTP is acquired (immunemediated) or congenital, and that the most common type - the acquired form - predominantly affects women in their 40s.

Specialized.

Description based on online resource; title from PDF title page (viewed on January 18, 2023).

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