TY - BOOK AU - Bleiberg, H TI - Management of colorectal cancer SN - 1853173770 PY - 1998/// CY - London PB - Martin Dunitz KW - Colorectal Cancer N1 - Key text (CCPC); Biology of colorectal cancer : an overview of genetic factors ; Some recent developments in the epidemiology of colorectal cancer ; Pathology of colorectal cancer ; Surgery of rectal cancer ; Left colectomy for cancer ; Surgery of metastatic disease ; Postoperative histopathological evaluation : implications for prognosis? ; Systematic adjuvant therapy of colon cancer ; Adjuvant intraportal treatment ; Guidelines for the safe administration of perioperative intraperitoneal chemotherapy ; Preoperative treatment of rectal cancer ; Adjuvant systemic treatment of colorectal cancer : duration of therapy ; The future of radiotherapy in rectal carcinoma ; Adjuvant treatment following curative resection of liver metastases from colorectal carcinoma ; How much are we convinced that adjuvant treatment is effective? ; Mechanism of drug action in colorectal cancer treatment ; Single-agent chemotherapy of colorectal cancer ; Metabolic modulation of 5-fluorouracil by high-dose leucovorin : preclinical rationale and clinical efficacy ; Modulation of 5-fluorouracil with folinic acid : high or low dose? ; Protracted infusion of 5-FU for colorectal cancer ; High-dose 24- or 48-hour infusion of 5-fluorouracil plus/minus folinic acid in the treatment of metastic colorectal cancer ; 5-fluorouracil and methotrexate in metastatic colorectal cancer ; The role of second-line chemotherapy in colorectal cancer ; Chronomodulation of chemotherapy against metastatic colorectal cancer ; Pharmacokinetic adjustment of chemotherapy ; Intrahepatic (locoregional chemotherapy for liver metastases from colorectal cancer ; New agents in the treatment of advanced colorectal cancer : irinotecan tomudex and oxaliplatin ; New chemotherapy approaches to colon cancer ; Postoperative treatment of rectal cancer ; Biological therapies for colonrectal cancer ; Quality of life in colorectal cancer randomized trials and meta-anlysis N2 - Offers a global view and a guide to the most promising research into colonrectal cancer and its management ER -