TY  - BOOK
AU  - Mackie, N
AU  - Phillips, A.N.
AU  - Kaye, S
AU  - Booth, C.
AU  - Geretti, A.M.
ED  - UK Resistance Database
ED  - UK Collaborative HIV Cohort Study
TI  - Antiretroviral drug resistance in HIV-1 infected patients with low-level viraemia
PY  - 2010///
N1  - NMUH Staff Publications; 201
N2  - This study characterized the prevalence and patterns of antiretroviral-drug-resistance mutations according to plasma human                     immunodeficiency virus type 1 (HIV-1) RNA load in a large population of patients with HIV-1 infection who underwent testing                     for resistance mutations in routine clinical practice. HIV-1 genotypic resistance test results with linked clinical data were                     obtained from national resistance and clinical databases in the United Kingdom. Among 7861 tests, detection of ⩾1 resistance                     mutation was most frequent at viral loads of 300–10,000 copies/mL and decreased statistically significantly at viral loads                     of >10,000 copies/mL. Major resistance mutations were commonly detected in the subset of tests that were performed among patients                     with viral loads of <1000 copies/mL (1001 [12.7%] of 7861 tests).We conclude that HIV-1 genotypic resistance testing is informative                     for patients with low viral loads.                  &nbsp
UR  - http://jid.oxfordjournals.org/content/201/9/1303.long
ER  -