TY  - BOOK
AU  - Frank, Steven A
TI  - Dynamics of cancer: Incidence, inheritance and evolution
T2  - Princeton series in evolutionary biology
SN  - 9780691133669
PY  - 2007///
CY  - Princeton
PB  - Princeton University Press
N1  - Monograph
N2  - <span style="font-size: 15.9991px; line-height: 21.9988px; font-family: "Times New Roman", serif;">The book provides a unique conceptual and historical framework for understanding the causes of </span><span class="term-highlight" style="font-size: 15.9991px; line-height: 21.9988px; font-family: "Times New Roman", serif;">cancer</span><span style="font-size: 15.9991px; line-height: 21.9988px; font-family: "Times New Roman", serif;"> and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary levels of analysis. He interprets a wide variety of observations on the age of </span><span class="term-highlight" style="font-size: 15.9991px; line-height: 21.9988px; font-family: "Times New Roman", serif;">cancer</span><span style="font-size: 15.9991px; line-height: 21.9988px; font-family: "Times New Roman", serif;"> onset, the genetic and environmental causes of disease, and the organization of tissues with regard to stem cell biology and somatic mutation. Frank uses new quantitative methods to tackle some of the classic problems in </span><span class="term-highlight" style="font-size: 15.9991px; line-height: 21.9988px; font-family: "Times New Roman", serif;">cancer</span><span style="font-size: 15.9991px; line-height: 21.9988px; font-family: "Times New Roman", serif;"> biology and aging: how the rate of increase in the incidence of lung </span><span class="term-highlight" style="font-size: 15.9991px; line-height: 21.9988px; font-family: "Times New Roman", serif;">cancer</span><span style="font-size: 15.9991px; line-height: 21.9988px; font-family: "Times New Roman", serif;"> declines after individuals quit smoking, the distinction between the dosage of a chemical carcinogen and the time of exposure, and the role of inherited genetic variation in familial patterns of </span><span class="term-highlight" style="font-size: 15.9991px; line-height: 21.9988px; font-family: "Times New Roman", serif;">cancer</span><span style="font-size: 15.9991px; line-height: 21.9988px; font-family: "Times New Roman", serif;">.</span&gt
UR  - http://www.ncbi.nlm.nih.gov/books/NBK1568/
ER  -