TY - BOOK AU - Frank, L.A. AU - Rabin, N. TI - Paraproteinaemia PY - 2015/// N1 - NMUH Staff Publications; 76 N2 - <span style="font-size: 10pt;">A paraprotein is a monoclonal immunoglobulinor immunoglobulin lightchain which is detected in the blood orurine. It arises from the clonal proliferationof mature B cells, usually plasma cellsor B-lymphocytes. Paraproteins are characterizedby a homogenous electrophoreticmigration and the expression of a singlelight chain type, either kappa or lambda.A raised paraprotein level can occur secondaryto malignant B-cell disorders,most commonly multiple myeloma, ormonoclonal gammopathy of uncertainsignificance, in which the detected paraproteinis at a low level. Paraproteinaemiacan also occur in other malignant conditions.This article helps the general physicianto know when to request serum andurine electrophoresis, which conditionsare associated with a paraprotein, and thedifferences between multiple myelomaand monoclonal gammopathy of uncertainsignificance.</span> UR - https://www.ncbi.nlm.nih.gov/pubmed/26053916 UR - http://www.magonlinelibrary.com/doi/abs/10.12968/hmed.2015.76.6.C82?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed ER -