TY - BOOK AU - Kumar, K. TI - Frequency and significance of indeterminate and borderline Quantiferon Gold TB IGRA results PY - 2017/// N1 - NMUH Staff Publications; 50 N2 - <span style="font-size: 10pt;">The Quantiferon Gold test is one of two commercially available tuberculosis (TB) interferon-γ release assays (IGRAs) recommended for the diagnosis of latent TB infection. A Quantiferon Gold test is considered positive if the result is ≥0.35 IU·mL</span><sup><span style="font-size: 10pt;">−1</span></sup><span style="font-size: 10pt;">. However, longitudinal studies have shown that a significant number of test reversions and conversions occur if results just above or below this threshold are repeated. This variation may be due to random chance or other factors such as test-related errors, differences in absolute lymphocyte numbers and within-subject variability of the interferon-γ response. The high proportion of conversions and reversions around the 0.35 IU·mL</span><sup><span style="font-size: 10pt;">−1</span></sup><span style="font-size: 10pt;"> cut-off has led some to suggest that a borderline or equivocal range should be used, as this avoids treatment of individuals who do not have a ‘stable’ positive result, as well as failure to treat those just below the 0.35 threshold who would convert to a positive result if the test were repeated.&nbsp;</span> UR - http://erj.ersjournals.com/content/50/4/1701267.long UR - http://ferriman.wufoo.com/forms/journal-article-request/ ER -