TY  - BOOK
AU  - Pui,Ching-Hon
TI  - Childhood leukemias 
T2  - Cambridge medicine
SN  - 9781139518239
PY  - 2012///
CY  - Cambridge
PB  - Cambridge University Press
KW  - Leukemia in children
KW  - Leukemia
KW  - Children
KW  - Child
N1  - Includes bibliographical references and index; Section I. History and General Issues: History of leukemia: historical perspectives / Paul S. Gaynon, Toska J. Zomorodian and Donald Pinkel -- Diagnosis and classification / Mihaela Onciu and Ching-Hon Pui -- Epidemiology and etiology / Logan G. Spector, Bridget Charbonneau and Leslie L. Robison -- Section II. Cell Biology and Pathobiology: Immunophenotyping / Frederick G. Behm -- Immunoglobulin and T-cell receptor gene rearrangements / Jacques J.M. van Dongen and Anton W. Langerak -- Cytogenetics of acute leukemias / Susana C. Raimondi -- Molecular genetics of acute lymphoblastic leukemias / Charles G. Mullighan -- Molecular genetics of acute myeloid leukemia / Tanja A. Gruber and James R. Downing -- Epigenetics of leukemia / William Stevenson and Guillermo Garcia-Manero -- Genetics and cellular drug resistance in acute leukemia / Monique L. den Boer and Rob Pieters -- Heritable predispositions to childhood hematologic malignancies / Alix E. Seif, Beverly J. Lange, Jaclyn A. Biegel, and Kim E. Nichols -- Section III. Evaluation and Treatment:- Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations / Stephen W. Paugh, Mary V. Relling and Williams E. Evans -- Acute lymphoblastic leukemia / Ching-Hon Pui -- Relapsed acute lymphoblastic leukemia / G�unter Henze and Arend von Stackelberg -- B-cell acute lymphoblastic leukemia and Burkitt lymphoma / John T. Sandlund and Mihaela Onciu -- Acute myeloid leukemia / Jeffrey E. Rubnitz, Hiroto Inaba and Raul C. Ribeiro; Relapsed acute myeloid leukemia / Ursula Creutzig -- Myelodysplastic syndrome / Henrik Hasle -- Chronic myeloproliferative disorders / Charlotte M. Niemeyer and Franco Locatelli -- Leukemias in patients with Down syndrome / Jeffrey W. Taub, April Sorrell and James A. Whitlock -- Treatment of adolescents and young adults with acute lymphoblastic leukemia / James Nachman -- Hematopoietic stem cell and natural killer cell transplantation / Wing Leung and Michael A. Pulsipher -- Treatment of acute leukemia in countries with limited resources / Raul C. Ribeiro, Scott C. Howard and Ching-Hon Pui -- Antibody-targeted therapy / Alan S. Wayne -- Adoptive cellular immunotherapy / Hyoung Jin Kang, Cliona M. Rooney and Helen E. Heslop -- Gene transfer: methods and applications / Ulrike Gerdemann, Martin Pule and Malcolm K. Brenner -- Development therapeutics / Sima Jeha -- Minimal residual disease / Dario Campana, Andrea Biondi and Jacques J.M. van Dongen -- Section IV. Complications and Supportive Care: Acute complications / Scott C. Howard, Raul C. Ribeiro and Ching-Hon Pui -- Late complications after leukemia therapy / Melissa M. Hudson -- Therapy-related leukemias / Carolyn A. Felix -- Infectious complications in leukemia / Hana Hakim and Patricia M. Flynn -- Hematologic supportive care / Fariba Navid and Victor M. Santana -- Pain management / Doralina L. Anghelescu and Roland Kaddoum -- Psychosocial issues / Sean Phipps, Vida L. Tyc, Heather Conklin and Kevin Krull -- Nursing care / Jami S. Gattuso, Martha May and Michele Chandler
N2  - "In the five years since publication of the second edition of Childhood Leukemias, new insights into the molecular and cellular biology of cancers in general, and of the leukemias in particular, have catalyzed exciting advances in diagnostic methods, strategies of risk assessment and the development of targeted and other novel forms of treatment. Encouraged by this progress, and the enthusiastic responses of readers of the previous edition, I willingly accepted the invitation to develop a third edition of this successful book. The rapid growth in our understanding of the biology of childhood leukemias and the accelerating pace of innovations in diagnostic and therapeutic approaches presented a considerable challenge during revision of the second edition. As you will notice, each chapter has been extensively modified or rewritten to accommodate the most recent information and references. Although structured to emphasize emerging themes in leukemia pathobiology and treatment, the reworked book still seeks to maintain a balance between fundamental pathophysiology and practical approaches to patient management, a standard that was central to the success of our earlier editions. Three chapters are entirely new. One deals with the epigenetics of leukemia, a topic that hasmoved rapidly to the fore of leukemia research. The discovery that aberrant epigenetic changes often cooperate with DNA sequence alterations in the initiation and progression of cancer, and that such changes are potentially reversible, has already led to clinical trials of therapies based on key epigenetic findings"--Provided by publisher; The most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases, from basic science to clinical management
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ER  -