TY - BOOK AU - Aliev,Gjumrakch TI - Role of oxidative stress, mitochondria failure, and cellular hypoperfusion in the context of Alzheimer disease: past, present and future T2 - Neurology--laboratory and clinical research developments SN - 9781619428973 PY - 2013///] CY - New York PB - Nova Science Publishers, Inc KW - Alzheimer's disease KW - Oxidative stress KW - Mitochondrial pathology KW - Cell respiration N1 - Includes bibliographical references and index; THE ROLE OF OXIDATIVE STRESS, MITOCHONDRIA FAILURE, AND CELLULAR HYPOPERFUSION IN THE CONTEXT OF ALZHEIMER DISEASE ; THE ROLE OF OXIDATIVE STRESS, MITOCHONDRIA FAILURE, AND CELLULAR HYPOPERFUSION IN THE CONTEXT OF ALZHEIMER DISEASE ; Dedication and Acknowledgments ; Contents ; Preface ; Are Mitochondrial Failures a Key Component in Alzheimer Disease? ; Abstract ; Acknowledgments ; References ; In Vivo and In Vitro Assessment of the Brain Mitochondrial Bioenergetics in Aging Rats ; Abstract ; Introduction ; Materials and Methods ; Animals ; Methods; In vivo 31P Magnetic Resonance Spectroscopy In Vitro Mitochondrial Respiration ; In Vitro Mitochondrial Oxidative Phosphorylation (Table 2 and Figure 2) ; Endogenous Antioxidants ; Statistical Methods ; Results ; In Vivo 31P Magnetic Resonance Spectroscopy ; Endogenous Antioxidants (Table 3 and Figure 3) ; Discussion ; Acknowledgments ; References ; The Pathophysiology of Cerebrovascular Lesions in Alzheimer Disease ; Abstract ; The Effect of Oxidative Stress on Brain Microvessel Function in AD ; Neuropathologic Features of Cerebrovascular Lesions; Hypoperfusion as a Factor in the Development of AD Relationships between Apolipoprotein E (ApoE) Genotype, Hypercholesterolemia, and Vascular Changes in AD ; Hypoxia/Ischemia/Reperfusion as Cofactors for Oxidative Stress Induced Cerebrovascular Lesions and their Relationship to AD ; The Role of Mitochondrial Abnormalities in the Patho-Genesis of Oxidative Stress-Induced Brain Lesions in AD ; The Role of Endothelial Vasoactive Substancesin the Pathophysiology of Brain Ischemia/Reperfusion and AD ; Transgenic Animals as Models for Studying Cerebrovascular Lesions in AD; Prevention of AD Using Selective Pharmacological Treatments Conclusion and Considerations for the Future; Acknowledgments ; References ; Vascular Pathology in the Pathogenesis of Alzheimer Disease ; I. Epidemiological Findings ; II. Elements of Brain Tissue Metabolism; III. Causes and Risk Factors ; Inflammatory System ; Vascular Pathology ; 1. Mitochondrial Dysfunction in AD ; 2. Hypoxia and AD ; 3. History of Stroke, Cerebral Ischemia and AD ; 4. Hypertension and Alzheimer Disease ; Acknowledgments ; References; Oxidative Stress Induced Mitochondrial Failure and Cellular Hypoperfusion as Primary Pathogenic Factors for the Development and Progression of Alzheimer Disease Abstract ; Introduction ; Cerebral Vascular Energy Requirements: Hypoperfusion as a Key Factor for the Development of AD ; The Effect of Oxidative Stress on Brain Microvessel Function and A Deposition in AD; Morphometric and Neuropathological Features of CerebroVascular Lesions and A in AD ; Relationships between ApoE Genotype, Hypercholesterolemia, A and Vascular Changes in AD UR - https://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=564952 ER -