TY  - BOOK
AU  - Kawaguchi,Takanori
TI  - Cancer metastasis and cancer stem cellniche
SN  - 9781681083476
PY  - 2016///
CY  - Sharjah
PB  - Bentham Science Publishers
KW  - Metastasis
KW  - Cancer
KW  - Stem cells
N1  - III-c. Plastic Cancer Stem Cell Model; FOREWORD ; PREFACE ; Biography ; List of Contributors ; Fundamental Relationships Between Cancer Stem Cells, the Cancer Stem Cell Niche and Metastasis ; INTRODUCTION; FEATURES OF STEMNESS; Stem Cells in Normal Physiology and Development; The Cancer Stem Cell Phenotype; Morphology, Differentiation and Self Renewal; Mitotic Activity; Protein and Biomarker Expression; Metabolism; Metastasis Initiating Cells; Critical Components of Metastasis; Epithelial-to-Mesenchymal Transition; Mechanisms of Metastasis; Contributions of the Niche; The Normal Stem Cell Niche; The CSC Niche; The Metastatic NicheCONCLUSION; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Regulation of Cell Surface Glycan Expression in Cancer Stem Cells ; INTRODUCTION; CANCER STEM CELLS AND EPIGENETIC SILENCING OF GLYCOGENES; Induction of Typical Cancer-associated Glycans Through Epigenetic Silencing of Glycan-related Genes Responsible for Synthesis of Normal Glycans; Mechanisms for Epigenetic Silencing of Glycan-related Genes During the Course of Carcinogenesis; Differentiation-dependent Expression of Glycans in Normal Tissue Stem Cells; ENHANCED STEMNESS AND ALTERED GLYCAN EXPRESSION BY TUMOR HYPOXIAAcquisition of Resistance to Hypoxia by Cancer Cells in Advanced Stage of Cancers; Normal Stem Cells and Their Hypoxic Niches; STEM CELLS AND GLYCAN ALTERATION IN EPITHELIO-MESENCHYMAL TRANSITION; Glycan Alteration in Epithelio-mesenchymal Transition of Cancer Cells; Normal Stem Cells and Plasticity to Undergo EMT/MET; GLYCANS ASSOCIATED WITH HUMAN EMBRYONIC STEM CELLS AND CANCER STEM CELLS; Appearance of Classical Human Embryonic Stem Cell Marker Glycans, SSEA-3/-4, in Cancer Stem Cells; Lactoseries Glycans Recently Emerging as Human Embryonic and Cancer Stem Cell MarkersCONCLUSION; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Tumor Endothelial Cells and Cancer Progression ; TUMOR ANGIOGENESIS; TUMOR BLOOD VESSELS ARE MORPHOLOGICALLY ABNORMAL; DIFFERENCES BETWEEN TUMOR ENDOTHELIAL CELLS AND NORMAL ENDOTHELIAL CELLS; HETEROGENEITY OF NORMAL ENDOTHELIAL CELLS; TEC HETEROGENEITY; DRUG RESISTANCE AND CYTOGENETIC ABNORMALITIES IN HM-TECS; MECHANISMS OF TEC HETEROGENEITY; CONCLUSION; FUNDING; DISCLOSURE; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Metastatic Cancer Stem Cell Niche and the Toll-like Receptor 4 (TLR4)-mediated Premetastatic Microenvironment I. OVERVIEW; I-a. Outline of Tumor Metastasis; I-b. Traffic Accident Theory; I-c. Organ Tropism of Tumor Metastasis; I-d. Pre-metastatic Phase; II. CANCER STEM CELL, RECENT PROGRESS; II-a. Definition of Cancer Stem Cell; II-b. Metastatic Stem Cell; II-c. Cancer Stem Cell and Markers; II-d. Cancer Stem Cells and EMT (Epithelial-mesenchymal Transition); II-e. Tumor Heterogeneity; III. CANCER STEM CELL MODELS; III-a. Clonal Evolution Model; III-b. Classical Cancer Stem Cell Model
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