Chesley's hypertensive disorders in pregnancy

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Introduction, history, controversies, and definitions -- The clinical spectrum of preeclampsia -- Epidemiology of pregnancy-related hypertension -- Genetic factors in the etiology of preeclampsia/eclampsia -- The placenta in normal pregnancy and preeclampsia -- Angiogenesis and preeclampsia -- Metabolic syndrome and preeclampsia -- Immunology of normal pregnancy and preeclampsia -- Endothelial cell dysfunction -- Animal models for investigating pathophysiological mechanisms of preeclampsia -- Tests to predict preeclampsia -- Prevention of preeclampsia and eclampsia -- Cerebrovascular pathophysiology in preeclampsia and eclampsia -- Cardiovascular alterations in normal and preeclamptic pregnancy -- The renin-angiotensin system, its autoantibodies, and body fluid volume in preeclampsia -- The kidney in normal pregnancy and preeclampsia -- Platelets, coagulation, and the liver -- Chronic hypertension and pregnancy -- Antihypertensive treatment -- Clinical management.

Includes bibliographical references and index.

Leon Chesley’s Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley’s Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia.