Genomic medicine : principles and practice [E-Book]

Includes bibliographical references at the end of each chapters and index.

Print version record.

Cover; Series; Genomic Medicine: Principles and Practice; Copyright; Dedication; Foreword; Foreword to the First Edition; Preface to the First Edition; Preface; Acknowledgments; Contents; Contributors; Part I: Principles of Genomic Medicine; 1. Genes, Genetics, and Human Genomics; 2. The human genome-structure and organization; 3. Human proteomics; 4. Epigenetics, epigenomics, and human disease; 5. Genes, genome, and developmental malformations; 6. Bioinformatics, systems biology, and systems medicine; 7. Pharmacogenomics-critical component of genomic medicine.

8. New drug development, drug response, and precision medicines9. Mitochondrial genetics and genomics in clinical medicine; 10. Genomics technology in clinical diagnostics; 11. Microbial genomics: targeted antimicrobial therapy and genome vaccines; 12. Nutritional genomics; 13. Genomics in public and population health; 14. Genetic testing and genomic screening; 15. Biobanking for genomics-based translational medicine; 16. Genetics and genomics education: the path from helix to health; 17. Ethical, legal, and social issues in clinical genomics; 18. The regulation of human genomics research.

Part II: Genomics in Clinical Practice19. Genetic and genomic approaches to clinical medicine; 20. Genetic and genomic taxonomy of human disease; 21. Genomics of complex cardiovascular disease; 22. Genomics of type 2 diabetes mellitus and obesity; 23. Genetics and genomics of osteoporosis and related disorders; 24. Genetics and genomics of chronic kidney disease; 25. Genetics and genomics in clinical hematology, I: Hemostasis and thrombosis; 26. Genetics and genomics in clinical hematology, II: Inherited disorders of hemoglobin.

27. Genetic and genomics in clinical hematology, III: Acute leukemias28. Genetics and genomics of chronic inflammatory disorders, I: Inflammatory bowel disease; 29. Genetics and genomics of chronic inflammatory disorders, II: Rheumatoid arthritis and related arthropathies; 30. Genetics and genomics of chronic inflammatory disorders, III: Bronchial asthma; 31. Genetics and genomics of neuro-psychiatric diseases, I: Seizure disorders; 32. Genetics and genomics of neuro-psychiatric diseases, II: Multiple sclerosis.

33. Genetics and genomics of neuro-psychiatric diseases, III: The common dementias34. Genetics and genomics of neuro-psychiatric diseases, IV: Schizophrenia and bipolar disorder; 35. Genetics and genomics of neuro-psychiatric diseases, V: Learning and behavioral disorders; 36. Clinical cancer genomics; 37. Genomics and infectious diseases: susceptibility, resistance, response, and antimicrobial therapy; 38. Genomic perspectives of clinical immunology; 39. Genomic applications in clinical pediatrics; 40. Genetics and genomics in clinical ophthalmology, I: The spectrum of genetic eye disease.

The first edition of Genomics and Clinical Medicine provided an overview of genomics-based advances in disease susceptibility, diagnosis, and prediction of treatment outcomes in various areas of medicine. Since its publication, the science of genomics has made tremendous progress, and exciting new developments in biotechnology and bioinformatics have created possibilities that were inconceivable only a few years ago. This completely revised second edition of Genomic Medicine reflects the rapidly changing face of applied and translational genomics in the medical and health context and provides a comprehensive coverage of principles of genetics and genomics relevant to the practice of medicine. The first section lays foundation to the practice of genomic medicine. New chapters in this section include bioinformatics, proteomics, microbial genomics and genomic education. Detailed discussions of genetic/genomic testing and screening and the ethical, legal, and social issues (ELSI) crucially address genethics and genomethics in the practice of Genomic Medicine. The second section includes clinical practice oriented chapters highlighting genomic applications (array comparative genomic hybridization, exome genome sequencing and new generation generation sequencing) in clinical diagnosis of congenital developmental malformations, Mendelian genetic disorders, and complex cardiovascular, neuro-psychiatric, ophthalmic, dermatologic, inflammatory and pediatric disorders. Separate chapters discuss microbial genomics with emphasis on the role of genomics in targeted antimicrobial therapy and development of genomic class of new vaccines. New developments in gene/ cell-based somatic therapy, regenerative medicine and targeted molecular therapy are discussed in respective chapters. All chapters are thoroughly indexed and supported by a carefully compiled glossary relevant to genetic and genomic medicine.