000			03046 a2200289 4500
008			190930b2019 xxu||||| |||| 00| 0 eng d
020			_a9781108447461
060			_aWM 402.
100	1		_aMeyer, Jonathan M
245	1	4	_aThe clozapine handbook
260			_aCambridge : _bCambridge University Press, _c2019.
300			_axi, 317p.
490			_aStahl's handbooks
490			_aCambridge medicine
500			_aCopyright date is 2020 but actually published in 2019.
505			_aPreface 1. Initiating Clozapine 2. Understanding hematologic monitoring and benign ethnic neutropenia 3. Binding profile, metabolism, kinetics, drug interactions and use of plasma levels 4. Managing constipation 5. Managing sialorrhea 6. Managing sedation, orthostasis and tachycardia 7. Managing metabolic adverse effects 8. Managing seizure risk and stuttering 9. Fever, myocarditis, interstitial nephritis, DRESS, serositis and cardiomyopathy 10. Eosinophilia, leukocytosis, thrombocytopenia, thrombocytosis, anemia, hepatic function abnormalities 11. Managing enuresis and incontinence, priapism, venous thromboembolism, neuroleptic malignant syndrome, tardive dyskinesia and obsessive compulsive disorder 12. The efficacy story: treatment resistant schizophrenia, psychogenic polydipsia, treatment intolerant schizophrenia, suicidality, violence, mania and Parkinson's disease psychosis 13. Addressing clozapine positive symptom nonresponse in schizophrenia spectrum patients 14. Discontinuing clozapine and management of cholinergic rebound 15. Special topics: child and adolescent patients, elderly patients, patients with intellectual disability, pregnancy and risk for major congenital malformation, lactation, overdose, postmortem redistribution Index.
520			_aReal-world and clinical trial data support that clozapine is the only effective antipsychotic for treatment resistant schizophrenia and other severe mental illnesses. Clozapine also reduces rates of suicidality, psychiatric hospitalization and all-cause mortality. However, clozapine is underutilized for two reasons: misunderstandings of its efficacy benefits and misapprehension of, limited knowledge or misinformation about the management of treatment related risks and adverse effects. In response to worldwide efforts to promote clozapine use, this user-friendly Handbook provides clinicians with evidence-based approaches for patient management, as well as logical approaches to the management of clinical situations and adverse effects. It outlines clearly the rationale for specific management decisions and prioritises the options based on this logic. This Handbook is designed for use by clinicians worldwide and is essential reading for all mental health care professionals.
650			_aPsychopharmacology
650			_aPsychotropic drugs _97615
650			_aPsychiatry
650			_aPsychotic disorders
650			_aDrug therapy
650			_aSchizophrenia
650			_aPrescription, drug
700	1		_aStahl, Stephen M
942			_n0
999			_c33653 _d33653