000 03676cam a2200277 4500
001 9781119341154
008 180406t2017 xxu||||| |||| 00| 0 eng d
020 _a9781119341154
020 _a1119341159 (electronic bk.)
100 _aSmall, William [Jr.,] (ed)
245 0 _aClinical radiation oncology : indications, techniques, and results
250 _aThird edition.
260 _aHoboken, NJ :
_bJohn Wiley & Sons, Inc.,
_c2017
300 _a1 online resource. : (electronic bk.)
505 _atext
505 _aClinical Radiation Oncology; Contents; Dedication; Preface; Contributors; Section 1 Scientific Foundations; 1 Basic Concepts of Clinical Radiation Oncology; Introduction; Planning and Preparation; Radiation Therapy in the Clinic; Combining Radiation Therapy with Surgery; Preoperative Radiation Therapy; Postoperative Radiation Therapy; Combining Radiation Therapy with Chemotherapy; Combining Radiation Therapy with Biologic Agents; Combining Radiation Therapy with Hormonal Agents; Radiosensitivity and Tumor Control Probability; Fractionation and Fraction Size
505 _aLinear Energy Transfer (LET) and Relative Biologic Effectiveness (RBE)Oxygen Enhancement Ratio; Radiocurable Tumors; Technological Advances in Radiotherapy; Intensity-Modulated Radiation Therapy (IMRT); Image-Guided Radiotherapy (IGRT); Stereotactic Radiosurgery (SRS)/Stereotactic Body Radiation Therapy (SBRT); Particle Beam Radiotherapy; Brachytherapy; Intraoperative Radiotherapy; Unsealed Sources; Hyperthermia; Radiation Complications; References; 2 Radiation Biology for Radiation Oncologists; DNA Damage, DNA Repair, and Cell Survival; DNA Damage After Irradiation
505 _aImmediate Biochemical Modification of Radiation-Induced DamageDNA Damage Sensing and DNA Repair; Modes of Cell Death Following DNA Damage; Biological Factors that Influence Radiation Response; The Oxygen Effect and the Significance of Hypoxia; Radiation Sensitivity, the Cell Cycle, and Checkpoints; Physical Parameters Affecting Radiation Response; Dose Rate; Linear Energy Transfer and Relative Biological Effectiveness; Tumor and Tissue Responses to Ionizing Radiation; Dose-Response Curves and the Therapeutic Window; Tumor Cell Radiation Sensitivity
505 _aDose-Response Curves for Tumors Irradiated In SituSlope of Dose-Response Curve and Heterogeneity in Treated Tumors; Tumor Volume and TCD50; Recurrent Tumors; Immune Reaction and Tumor Response; Normal Tissue Response; Attempts to Reduce the Impact of Hypoxic Cells on Tumor Resistance; Dose Fractionation and Tissue Response; Biological Significance of Dose Fractionation; Models of Fractionation Dependence; Combination of Radiation and Chemotherapeutic Agents: Cytotoxics, Sensitizers, and Protectors; Radiation Protectors; Rationale for the Combination of Surgery and Radiotherapy
505 _aNew Approaches to Optimize Radiation TherapyInhibition of Kinase-Dependent Signaling Pathways to Enhance Radiotherapy; Modulation of Apoptosis to Increase Tumor Cell Kill or Protect Normal Tissues; Angiogenesis as a Target for Cancer Therapy; Summary; References; 3 Treatment Planning; Introduction; Imaging; Imaging for Treatment Planning; Computed Tomography; Magnetic Resonance Imaging; Emission Tomography; Image Processing; Image Registration; Deformable Image Registration (DIR); Image Segmentation; Dose Calculations; Single-Field Dosimetry
520 _aRemote
520 _aIncludes bibliographical references and index.
700 _aTarbell, Nancy J. [1951-] (ed)
700 _aYao, Min [(Radiation oncologist),] (ed)
856 _uhttp://dx.doi.org/10.1002/9781119341154
_y[Wiley Online Library]
999 _c57774
_d57774