000			01853cam a2200229 4500
001			NMDX5953
008			120401t2010 xxu||||| |||| 00| 0 eng d
100			_aMackie, N
240			_aJournal of Infectious Diseases
245			_aAntiretroviral drug resistance in HIV-1 infected patients with low-level viraemia.
260			_c2010
500			_aNMUH Staff Publications
500			_a201
520			_aThis study characterized the prevalence and patterns of antiretroviral-drug-resistance mutations according to plasma human immunodeficiency virus type 1 (HIV-1) RNA load in a large population of patients with HIV-1 infection who underwent testing for resistance mutations in routine clinical practice. HIV-1 genotypic resistance test results with linked clinical data were obtained from national resistance and clinical databases in the United Kingdom. Among 7861 tests, detection of ⩾1 resistance mutation was most frequent at viral loads of 300–10,000 copies/mL and decreased statistically significantly at viral loads of >10,000 copies/mL. Major resistance mutations were commonly detected in the subset of tests that were performed among patients with viral loads of <1000 copies/mL (1001 [12.7%] of 7861 tests).We conclude that HIV-1 genotypic resistance testing is informative for patients with low viral loads.                   
700			_aPhillips, A.N.
700			_aKaye, S
700			_aBooth, C.
700			_aGeretti, A.M.
710			_aUK Resistance Database
710			_aUK Collaborative HIV Cohort Study
856			_uhttp://jid.oxfordjournals.org/content/201/9/1303.long
999			_c75427 _d75427