| 000 | 01504cam a2200181 4500 | ||
|---|---|---|---|
| 001 | NMDX6984 | ||
| 008 | 120401t2015 xxu||||| |||| 00| 0 eng d | ||
| 100 | _aFrank, L.A. | ||
| 240 | _aBritish Journal of Hospital Medicine | ||
| 245 | _aParaproteinaemia | ||
| 260 | _c2015 | ||
| 500 | _aNMUH Staff Publications | ||
| 500 | _a76 | ||
| 520 | _a<span style="font-size: 10pt;">A paraprotein is a monoclonal immunoglobulinor immunoglobulin lightchain which is detected in the blood orurine. It arises from the clonal proliferationof mature B cells, usually plasma cellsor B-lymphocytes. Paraproteins are characterizedby a homogenous electrophoreticmigration and the expression of a singlelight chain type, either kappa or lambda.A raised paraprotein level can occur secondaryto malignant B-cell disorders,most commonly multiple myeloma, ormonoclonal gammopathy of uncertainsignificance, in which the detected paraproteinis at a low level. Paraproteinaemiacan also occur in other malignant conditions.This article helps the general physicianto know when to request serum andurine electrophoresis, which conditionsare associated with a paraprotein, and thedifferences between multiple myelomaand monoclonal gammopathy of uncertainsignificance.</span> | ||
| 700 | _aRabin, N. | ||
| 856 | _uhttps://www.ncbi.nlm.nih.gov/pubmed/26053916 | ||
| 856 | _uhttp://www.magonlinelibrary.com/doi/abs/10.12968/hmed.2015.76.6.C82?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed | ||
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_c76000 _d76000 |
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