000			01528cam a2200193 4500
001			NMDX7023
008			120401t2014 xxu||||| |||| 00| 0 eng d
100			_aKumar, K.
240			_aBMJ Case Reports
245			_aA curious case of cholestasis: oral terbinafine associated with cholestatic jaundice and subsequent erythema nodosum
260			_c2014
500			_aNMUH Staff Publications
520			_a<span style="font-size: 10pt;">Terbinafine is a commonly prescribed antifungal agent used in the treatment of trichophytic onychomycosis and chronic cutaneous mycosis that are resistant to other treatments. This case report highlights a rarely documented but important adverse hepatic reaction that was caused by the use of oral terbinafine. A woman in her thirties presented with a 3-week history of jaundice, malaise, itching, nausea, decreased appetite, weight loss, dark orange urine and intermittent non-radiating epigastric pain. She had recently finished a 3-week course of oral terbinafine for a fungal nail infection. Liver biopsy findings were consistent with chronic active hepatitis secondary to a drug reaction. A few days after initial presentation, the patient developed erythema nodosum. Delayed development of erythema nodosum secondary to terbinafine could not be excluded.</span>
700			_aGill, A.
700			_aShafei, R.
700			_aWright, J.L.
856			_uhttps://www.ncbi.nlm.nih.gov/pubmed/25480138
856			_uhttp://casereports.bmj.com/content/2014/bcr-2014-205331.long
999			_c76034 _d76034