000			01377cam a2200181 4500
001			NMDX7049
008			120401t2014 xxu||||| |||| 00| 0 eng d
100			_aEwing, I.
240			_aFrontline Gastroenterology
245			_aThe molecular genetics of colorectal cancer
260			_c2014
500			_aNMUH Staff Publications
500			_a5
520			_a<span style="font-size: 10pt;">Colorectal cancer is a common but heterogeneous disease, which arises through the accumulation of genetic mutations. Knowledge of the molecular basis of colorectal cancer has advanced at a rapid pace in recent years, reflecting progress made in the field of genomic medicine. Targeted therapies have come into mainstream use, and the exciting prospect of treatment regimens tailored to the mutation profile of individual tumours is beginning to emerge. In order to understand the development and application of the next generation of colorectal cancer treatments, it is important that gastroenterologists have a working knowledge of the pathological mechanisms that drive the disease. This review examines our current understanding of the molecular genetics of colorectal carcinogenesis.</span>
700			_aMillar, A.
856			_uhttps://www.ncbi.nlm.nih.gov/pubmed/24416503
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880905/pdf/flgastro-2013-100329.pdf
999			_c76054 _d76054