| 000 | 01611cam a2200181 4500 | ||
|---|---|---|---|
| 001 | NMDX7177 | ||
| 008 | 120401t2007 xxu||||| |||| 00| 0 eng d | ||
| 100 | _aWaters, A. | ||
| 240 | _aJournal of Infectious Diseases | ||
| 245 | _aReconstitution of herpes simplex virus-specific T cell immunity in HIV-infected patients receiving highly active antiretroviral therapy | ||
| 260 | _c2007 | ||
| 500 | _aNMUH Staff Publications | ||
| 500 | _a195 | ||
| 520 | _a<span style="font-size: 10pt;">Production of herpes simplex virus (HSV)-specific interferon- gamma by peripheral-blood mononuclear cells (PBMCs) of HSV-seropositive healthy donors and human immunodeficiency virus-infected persons was determined by use of ELISPOT. The mean +/- SD number of spot-forming cells/10(6) PBMCs was 314 +/- 74 in 11 healthy donors, 360 +/- 69 in 3 long-term nonprogressors (LTNPs), 186 +/- 52 in 9 newly diagnosed patients, and 181 +/- 59 in 33 patients who were receiving highly active antiretroviral therapy (HAART) for a median period of 30 months (range, 1-109 months). In 9 patients monitored prospectively while receiving virologically and immunologically successful first-line HAART, the number of spot-forming cells increased by 5.6/month (95% confidence interval, 1.2-9.9 [P=.01]) and 21.3/100 CD4 cells/mm(3) gained (95% confidence interval, 13.8-28.7 [P&lt;.0001]). Responses were correlated with LTNP status and CD4 cell count.</span> | ||
| 700 | _aAinsworth, J. | ||
| 856 | _uhttps://www.ncbi.nlm.nih.gov/pubmed/17205480 | ||
| 856 | _uhttps://academic.oup.com/jid/article-lookup/doi/10.1086/510623 | ||
| 999 |
_c76166 _d76166 |
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