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008 080327s2008 njua obf 001 0 eng d
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020 _a9780470249055
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020 _a0470249021
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020 _a1281237418
020 _a9781281237415
020 _z9780470248478
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024 7 _a10.1002/9780470249055
_2doi
035 _a225452
_b(N$T)
035 _a(OCoLC)214281935
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037 _a10.1002/9780470249055
_bWiley InterScience
_nhttp://www3.interscience.wiley.com
060 4 _aQV 744
_bP9225 2008
072 7 _aMED
_x071000
_2bisacsh
072 7 _aMMG
_2bicssc
049 _aMAIN
245 0 0 _aPreclinical development handbook.
_pADME and biopharmaceutical properties /
_c
_h[E-Book]
246 3 0 _aADME and biopharmaceutical properties
260 _aHoboken, N.J. :
_bWiley-Interscience,
_c2008.
300 _a1 online resource (xv, 1329 pages) :
_billustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aPharmaceutical Development Series
504 _aIncludes bibliographical references and index.
588 0 _aPrint version record.
520 _aThis book gives the professional pharmaceutical scientist a basic and comprehensive tool to facilitate the preclinical development process by bringing together an overview of the preclinical process and a compendium of methods and techniques that need to.
505 0 _aPRECLINICAL DEVELOPMENT HANDBOOK ADME and Biopharmaceutical Properties; CONTRIBUTORS; CONTENTS; Preface; 1 Modeling and Informatics in Drug Design; 2 Computer Techniques: Identifying Similarities Between Small Molecules; 3 Protein-Protein Interactions; 4 Method Development for Preclinical Bioanalytical Support; 5 Analytical Chemistry Methods: Developments and Validation; 6 Chemical and Physical Characterizations of Potential New Chemical Entity; 7 Permeability Assessment; 8 How and Where Are Drugs Absorbed?; 9 Absorption of Drugs after Oral Administration
505 8 _a10 Distribution: Movement of Drugs through the Body11 The Blood-Brain Barrier and Its Effect on Absorption and Distribution; 12 Transporter Interactions in the ADME Pathway of Drugs; 13 Accumulation of Drugs in Tissues; 14 Salt and Cocrystal Form Selection; 15 Dissolution; 16 Stability: Physical and Chemical; 17 Dosage Formulation; 18 Cytochrome P450 Enzymes; 19 Metabolism Kinetics; 20 Drug Clearance; 21 In Vitro Metabolism in Preclinical Drug Development; 22 Utilization of In Vitro Cytochrome P450 Inhibition Data for Projecting Clinical Drug-Drug Interactions
505 8 _a23 In Vivo Metabolism in Preclinical Drug Development24 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Scientific Concepts and Practical Considerations; 25 Mechanisms and Consequences of Drug-Drug Interactions; 26 Species Comparison of Metabolism in Microsomes and Hepatocytes; 27 Metabolite Profiling and Structural Identification; 28 Linkage between Toxicology of Drugs and Metabolism; 29 Allometric Scaling; 30 Interrelationship between Pharmacokinetics and Metabolism; 31 Experimental Design Considerations in Pharmacokinetic Studies; 32 Bioavailability and Bioequivalence Studies
505 8 _a33 Mass Balance Studies34 Pharmacodynamics; 35 Physiologically Based Pharmacokinetic Modeling; 36 Mathematical Modeling as a New Approach for Improving the Efficacy/Toxicity Profile of Drugs: The Thrombocytopenia Case Study; 37 Regulatory Requirements for INDs/FIH (First in Human) Studies; 38 Data Analysis; Index
590 _aWorldCat record variable field(s) change: 650
650 0 _aPharmacokinetics
_vHandbooks, manuals, etc.
650 0 _aDrug development
_vHandbooks, manuals, etc.
650 0 _aDrugs
_xDesign.
650 0 _aComputer simulation.
650 0 _aDigital computer simulation.
650 0 _aChemical models.
650 1 2 _aDrug Design
650 2 2 _aComputational Biology
_xmethods
650 2 2 _aComputer Simulation
650 2 2 _aModels, Chemical
650 2 2 _aPharmaceutical Preparations
_xmetabolism
700 1 _aGad, Shayne C.,
_d1948-
830 0 _aPharmaceutical Development Series.
856 4 0 _uhttps://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=225452
_yKingston Hospital NHS Foundation Trust OpenAthens account holders click here for access
938 _aBaker and Taylor
_bBTCP
_nBK0007504472
938 _aEBL - Ebook Library
_bEBLB
_nEBL333797
938 _aebrary
_bEBRY
_nebr10226748
938 _aEBSCOhost
_bEBSC
_n225452
938 _aProQuest MyiLibrary Digital eBook Collection
_bIDEB
_n123741
938 _aYBP Library Services
_bYANK
_n2940099
938 _aYBP Library Services
_bYANK
_n2796393
942 _n0
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