000 | 06240cam a2200805 a 4500 | ||
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001 | ocn214281935 | ||
003 | OCoLC | ||
005 | 20221128211129.0 | ||
006 | m d | ||
007 | cr cn||||||||| | ||
008 | 080327s2008 njua obf 001 0 eng d | ||
040 |
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020 | _a9780470249055 | ||
020 | _a0470249056 | ||
020 |
_a9780470249024 _q(electronic bk.) |
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020 |
_a0470249021 _q(electronic bk.) |
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020 | _a1281237418 | ||
020 | _a9781281237415 | ||
020 |
_z9780470248478 _q(cloth) |
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020 |
_z0470248475 _q(cloth) |
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024 | 7 |
_a10.1002/9780470249055 _2doi |
|
035 |
_a225452 _b(N$T) |
||
035 |
_a(OCoLC)214281935 _z(OCoLC)179844166 _z(OCoLC)228416499 _z(OCoLC)476138555 _z(OCoLC)505113439 _z(OCoLC)646743032 _z(OCoLC)806201426 _z(OCoLC)815556284 _z(OCoLC)961621964 _z(OCoLC)962689282 _z(OCoLC)965976119 _z(OCoLC)988501320 _z(OCoLC)992087967 _z(OCoLC)1037735454 _z(OCoLC)1038668017 _z(OCoLC)1045485710 _z(OCoLC)1055347529 _z(OCoLC)1059043471 _z(OCoLC)1066416415 _z(OCoLC)1081280772 _z(OCoLC)1097109031 _z(OCoLC)1228528549 |
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037 |
_a10.1002/9780470249055 _bWiley InterScience _nhttp://www3.interscience.wiley.com |
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060 | 4 |
_aQV 744 _bP9225 2008 |
|
072 | 7 |
_aMED _x071000 _2bisacsh |
|
072 | 7 |
_aMMG _2bicssc |
|
049 | _aMAIN | ||
245 | 0 | 0 |
_aPreclinical development handbook. _pADME and biopharmaceutical properties / _c _h[E-Book] |
246 | 3 | 0 | _aADME and biopharmaceutical properties |
260 |
_aHoboken, N.J. : _bWiley-Interscience, _c2008. |
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300 |
_a1 online resource (xv, 1329 pages) : _billustrations |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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490 | 1 | _aPharmaceutical Development Series | |
504 | _aIncludes bibliographical references and index. | ||
588 | 0 | _aPrint version record. | |
520 | _aThis book gives the professional pharmaceutical scientist a basic and comprehensive tool to facilitate the preclinical development process by bringing together an overview of the preclinical process and a compendium of methods and techniques that need to. | ||
505 | 0 | _aPRECLINICAL DEVELOPMENT HANDBOOK ADME and Biopharmaceutical Properties; CONTRIBUTORS; CONTENTS; Preface; 1 Modeling and Informatics in Drug Design; 2 Computer Techniques: Identifying Similarities Between Small Molecules; 3 Protein-Protein Interactions; 4 Method Development for Preclinical Bioanalytical Support; 5 Analytical Chemistry Methods: Developments and Validation; 6 Chemical and Physical Characterizations of Potential New Chemical Entity; 7 Permeability Assessment; 8 How and Where Are Drugs Absorbed?; 9 Absorption of Drugs after Oral Administration | |
505 | 8 | _a10 Distribution: Movement of Drugs through the Body11 The Blood-Brain Barrier and Its Effect on Absorption and Distribution; 12 Transporter Interactions in the ADME Pathway of Drugs; 13 Accumulation of Drugs in Tissues; 14 Salt and Cocrystal Form Selection; 15 Dissolution; 16 Stability: Physical and Chemical; 17 Dosage Formulation; 18 Cytochrome P450 Enzymes; 19 Metabolism Kinetics; 20 Drug Clearance; 21 In Vitro Metabolism in Preclinical Drug Development; 22 Utilization of In Vitro Cytochrome P450 Inhibition Data for Projecting Clinical Drug-Drug Interactions | |
505 | 8 | _a23 In Vivo Metabolism in Preclinical Drug Development24 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Scientific Concepts and Practical Considerations; 25 Mechanisms and Consequences of Drug-Drug Interactions; 26 Species Comparison of Metabolism in Microsomes and Hepatocytes; 27 Metabolite Profiling and Structural Identification; 28 Linkage between Toxicology of Drugs and Metabolism; 29 Allometric Scaling; 30 Interrelationship between Pharmacokinetics and Metabolism; 31 Experimental Design Considerations in Pharmacokinetic Studies; 32 Bioavailability and Bioequivalence Studies | |
505 | 8 | _a33 Mass Balance Studies34 Pharmacodynamics; 35 Physiologically Based Pharmacokinetic Modeling; 36 Mathematical Modeling as a New Approach for Improving the Efficacy/Toxicity Profile of Drugs: The Thrombocytopenia Case Study; 37 Regulatory Requirements for INDs/FIH (First in Human) Studies; 38 Data Analysis; Index | |
590 | _aWorldCat record variable field(s) change: 650 | ||
650 | 0 |
_aPharmacokinetics _vHandbooks, manuals, etc. |
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650 | 0 |
_aDrug development _vHandbooks, manuals, etc. |
|
650 | 0 |
_aDrugs _xDesign. |
|
650 | 0 | _aComputer simulation. | |
650 | 0 | _aDigital computer simulation. | |
650 | 0 | _aChemical models. | |
650 | 1 | 2 | _aDrug Design |
650 | 2 | 2 |
_aComputational Biology _xmethods |
650 | 2 | 2 | _aComputer Simulation |
650 | 2 | 2 | _aModels, Chemical |
650 | 2 | 2 |
_aPharmaceutical Preparations _xmetabolism |
700 | 1 |
_aGad, Shayne C., _d1948- |
|
830 | 0 | _aPharmaceutical Development Series. | |
856 | 4 | 0 |
_uhttps://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=225452 _yKingston Hospital NHS Foundation Trust OpenAthens account holders click here for access |
938 |
_aBaker and Taylor _bBTCP _nBK0007504472 |
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938 |
_aEBL - Ebook Library _bEBLB _nEBL333797 |
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938 |
_aebrary _bEBRY _nebr10226748 |
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938 |
_aEBSCOhost _bEBSC _n225452 |
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938 |
_aProQuest MyiLibrary Digital eBook Collection _bIDEB _n123741 |
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_aYBP Library Services _bYANK _n2940099 |
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938 |
_aYBP Library Services _bYANK _n2796393 |
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999 |
_c89511 _d89511 |