000 04953cam a2200529Ia 4500
001 ocn228300466
003 OCoLC
005 20221128211130.0
006 m d
007 cr cn|||||||||
008 080519s2008 ne ab ob 001 0 eng d
040 _aOPELS
_beng
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019 _a232566396
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020 _a9780444531728
020 _a0444531726
020 _a9780080570303
_q(electronic bk.)
020 _a0080570305
_q(electronic bk.)
035 _a(OCoLC)228300466
_z(OCoLC)232566396
_z(OCoLC)476156515
_z(OCoLC)505072817
_z(OCoLC)646740879
_z(OCoLC)705540334
_z(OCoLC)823833291
_z(OCoLC)823902036
_z(OCoLC)824093080
_z(OCoLC)824144268
037 _a141235:141378
_bElsevier Science & Technology
_nhttp://www.sciencedirect.com
072 7 _aMED
_x044000
_2bisacsh
049 _aMAIN
245 0 0 _aEndocrine manifestations of systemic autoimmune diseases
_h[electronic resource] /
_c
260 _aAmsterdam :
_bElsevier Science,
_c2008.
300 _a1 online resource (xvii, 330 pages, [3] pages of plates) :
_billustrations (some color), 1 map
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aHandbook of systemic autoimmune diseases,
_x1571-5078 ;
_vv. 9
504 _aIncludes bibliographical references and index.
520 _aThis book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutical management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including the effects on elderly. The perturbations of the HPA axis as source of altered steroidal sythesis will be discussed and related to some interesting pathological conditions often complicating the autoimmune rheumatic diseases susch as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section in Pediatrics. *The premier issue evaluating the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements *Documents the latest research and indicate recent and coming new therapeutical-biological approaches to the therapy *The book will present therapeutical perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis.
505 0 _aPATHOPHYSIOLOGY: -- Neuroendocrine Immune Control Mechanisms and their influence on autoimmune disease; -- Sex Steroids, the immune system and autoimmune disease; -- Autoimmune disease and influence of sex hormones in experimental animals; -- Genetics of Autoimmune Endocrine Diseases; -- CLINICAL: -- Pituitary; -- Thyroid Dysfunction in Autoimmune Diseases; -- Adrenal Dysfunction and Autoimmune Disease; -- Endometriosis; Genetic abnormalities, hormones and autoimmune diseases; Polyglandular Autoimmune Endocrine Disease; -- Diabetes Type 1; -- Autoantibodies and Infertility in Autoimmune Diseases; -- Systemic Lupus Erythematosus and Endocrine Disorders; -- Pregnancy, neuroendocrine immune system and autoimmune diseases; -- HORMONAL MODULATION IN THE THERAPY OF AUTOIMMUNE DISEASES: -- Ovarian Function and its preservation in Autoimmune Diseases; Corticosteroids; -- Prolactin; -- DHEA; -- Adenosine agonists; -- NOVEL THERAPIES: -- New Treatments for Graves? Disease; -- Anti-TNF therapy -- modulation of hormone axes; -- Islet-cell transplantation; -- "Immune Intervention in Type 1 Diabetes: Realities of Today and Hopes for Tomorrow."
588 0 _aPrint version record.
650 0 _aEndocrine manifestations of general diseases.
650 0 _aAutoimmune diseases
_xEndocrine aspects.
700 1 _aWalker, Sara E.
700 1 _aJara, Luis J.,
_d1948-
830 0 _aHandbook of systemic autoimmune diseases ;
_vv. 9.
_x1571-5078
856 4 0 _uhttps://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=227597
_yKingston Hospital NHS Foundation Trust OpenAthens account holders click here for access
938 _aCoutts Information Services
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938 _aEBL - Ebook Library
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938 _aEBSCOhost
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938 _aIngram Digital eBook Collection
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938 _aYBP Library Services
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