000			06209cam a2200781Mu 4500
001			ocn796384275
003			OCoLC
005			20221128211844.0
006			m d
007			cr |n|||||||||
008			120625s2012 gw ob 001 0 eng d
040			_aEBLCP _beng _epn _cEBLCP _dIDEBK _dOCLCQ _dDEBBG _dCHVBK _dDEBSZ _dYDXCP _dE7B _dUAB _dCDX _dN$T _dNLGGC _dOCLCQ
019			_a805654668
020			_a9783110279351
020			_a3110279355
020			_a9783110279344
020			_a3110279347
020			_z9783110278996
020			_z3110278995
035			_a(OCoLC)796384275 _z(OCoLC)805654668
060		4	_a2012 F-294
060		4	_aWI 703
072		7	_aQP _2lcco
072		7	_aMED _x060000 _2bisacsh
049			_aMAIN
100	1		_aKeitel, Verena.
245	1	0	_aHepatobiliary Transport in Health and Disease _h[electronic resource].
260			_aBerlin : _bDe Gruyter, _c2012.
300			_a1 online resource (312 pages)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
588	0		_aPrint version record.
505	0		_aPreface; List of Contributors; Abbreviations; 1 Physiology of bile formation: Hepatocellular bile salt transporters; 1.1 Introduction; 1.2 Sodium-dependent bile salt uptake into hepatocytes; 1.3 Sodium-independent bile salt uptake into hepatocytes; 1.4 Bile salt export across the canalicular membrane; 1.5 Bile salt salvage systems; 1.6 Concluding remarks; 1.7 References; 2 Structure and function of hepatic ABC transporters; 2.1 Introduction to human ABC transporters expressed in the liver; 2.2 Structure and function of the bile salt export pump (ABCB11; BSEP).
505	8		_a2.3 Structure and function of the multidrug resistance protein 3 (ABCB4 MDR3); 2.4 Structure and function of the breast cancer resistance protein (ABCG2; BCRP); 2.5 Concluding remarks; 2.6 References; 3 Short- and long-term regulation of hepatobiliary transport; 3.1 Introduction; 3.2 Short-term regulation of sinusoidal transport systems; 3.3 Long-term regulation of sinusoidal transport systems; 3.4 Short-term regulation of canalicular secretion; 3.5 Long-term regulation of canalicular transport systems; 3.6 Methods of studying subcellular transporter distribution; 3.7 Summary; 3.8 References.
505	8		_a4 Nuclear bile acid receptor FXR and hepatobiliary transport systems4.1 Introduction; 4.2 Nuclear receptors; 4.3 Bile acids and the enterohepatic circulation; 4.4 Bile acid homeostasis, enterohepatic circulation, and FXR; 4.5 The role of FXR in the pathogenesis of biliary diseases; 4.6 Concluding remarks; 4.7 References; 5 Bile acid signaling in the liver and the biliary tree; 5.1 Introduction; 5.2 Bile acid signaling in liver parenchymal cells (hepatocytes); 5.3 Bile acid signaling in sinusoidal endothelial cells; 5.4 Bile acid signaling in Kupffer cells.
505	8		_a5.5 Bile acid signaling in hepatic stellate cells5.6 Bile acid signaling in the biliary tree; 5.7 References; 6 Modulation of innate immunity and inflammation by bile acids and their receptors; 6.1 Introduction; 6.2 Impact of FXR deletion on immunity and inflammation -- lessons from FXR knockout mice; 6.3 Role of TGR5 in the modulation of immune function; 6.4 Effects of bile acids on immunological function independently of bile acid receptors; 6.5 Obstructive jaundice and its impact on immune function; 6.6 Role of bile acids and FXR in viral infections; 6.7 Concluding remarks; 6.8 References.
505	8		_a7 Bile acids as extrahepatic and interorgan signaling molecules7.1 Introduction; 7.2 Bile acid-dependent modulation of glucose homeostasis; 7.3 Impact of bile acids on energy expenditure; 7.4 Bile acid receptors and immune response; 7.5 Role of bile acid receptors in the cardiovascular system; 7.6 Role of bile acid receptors in the kidney; 7.7 Bile acid receptors in the central and peripheral nervous system; 7.8 Summary and future perspectives; 7.9 References; 8 Disorders of bile duct development; 8.1 Introduction.
500			_a8.2 Morphogenesis of the intrahepatic bile duct epithelium: molecular players involved and their relationship with arterial morphogenesis.
520			_aThe transport systems involved in hepatobiliary transport have been cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. This book provides surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease. The book will be of interest for biochemists, structural chemists, biologists and clinicians.
504			_aIncludes bibliographical references and index.
650		0	_aLiver _xMetabolism.
650		0	_aBiliary tract _xMetabolism.
650		0	_aBiological transport.
650		0	_aLiver _xMetabolism _xDisorders.
650		0	_aBiliary tract _xMetabolism _xDisorders.
650		2	_aLiver _xmetabolism.
650		2	_aBile Acids and Salts _xmetabolism.
650		2	_aBiological Transport.
650		2	_aOrganic Anion Transporters, Sodium-Dependent.
650		2	_aOrganic Anion Transporters, Sodium-Independent.
650		4	_aBile Acids and Salts _xmetabolism.
650		4	_aBiological Transport.
650		4	_aLiver _xmetabolism.
650		4	_aOrganic Anion Transporters, Sodium-Dependent.
650		4	_aOrganic Anion Transporters, Sodium-Independent.
700	1		_aKubitz, Ralf.
700	1		_aH�aussinger, Dieter.
856	4	0	_uhttps://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=471030 _yKingston Hospital NHS Foundation Trust OpenAthens account holders click here for access
938			_aCoutts Information Services _bCOUT _n24364371 _c182.00 USD
938			_aEBL - Ebook Library _bEBLB _nEBL893693
938			_aebrary _bEBRY _nebr10582267
938			_aEBSCOhost _bEBSC _n471030
938			_aIngram Digital eBook Collection _bIDEB _n417050
938			_aYBP Library Services _bYANK _n7624854
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