000			04984cam a2200577 i 4500
001			ocn829236612
003			OCoLC
005			20221128212141.0
006			m d
007			cr |||||||||||
008			120503t20122012nyua ob 001 0 eng
010			_a 2020686181
040			_aDLC _beng _erda _cDLC _dYDXCP _dE7B _dOCLCF _dEBLCP _dAU@ _dSTF _dN$T
020			_a9781622570560 _qebook
020			_a1622570561
020			_z9781622570423 _qhardcover
020			_z1622570421
035			_a535131 _b(N$T)
035			_a(OCoLC)829236612
042			_apcc
072		7	_aHEA _x039110 _2bisacsh
072		7	_aMED _x056000 _2bisacsh
049			_aMAIN
245	0	0	_aNeurological disorders : _bnew research _c _h[E-Book]
264		1	_aNew York : _bNova Biomedical, Science Science Publishers, Incorporated, _c[2012]
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	0		_aNeuroscience research process
490	0		_aNeurology--laboratory and clinical research developments
504			_aIncludes bibliographical references and index.
588			_aDescription based on print version record and cip data provided by publisher.
505	0		_aNEUROLOGICAL DISORDERS ; NEUROLOGICAL DISORDERS ; Contents; Preface; Advanced Structural and Functional MRI Techniques in Parkinson's Disease; Abstract; Introduction; MR Morphometry; Diffusion MR Imaging; Functional MRI; Motor fMRI; Cognitive fMRI; Resting-State fMRI; Conclusion; References; Neuropoietic Cytokines and Neural Injury: Alterations in JAK2/STAT3 Signaling Associated with Aging; Abstract; 1. Introduction; 1.1. Neuropoietic Cytokine Family; 1.2. Role of the gp130 Cytokine Receptor Complex; 1.3. Role of Janus Kinases (Jaks)
505	8		_a1.4. Activation of Signal Transducer and Activator of Transcription 3 (STAT3)1.5. Effects of Phospho-STAT3 (pSTAT3); Cell Survival; Remodeling the Cellular Environment; Regulating Oxidative Stress; Immune Tolerance; Role of the Phosphorylation Site; 1.6. Regulating pSTAT3: Role of Negative Regulators; Suppressors of Cytokine Signaling (SOCS); Protein Inhibitors of Activated Stats (PIAS); Protein Tyrosine Phosphatases (PTP); 2. Discussion; 2.1. Changes in Neural Injury; Stroke; Traumatic Brain Injury; 2.2. JAK2/STAT3 Regulation Altered with Aging; 2.3. Significance of Phosphorylation Site.
505	8		_a3. Future Directions3.1. Elucidate the Role of STAT3 across Cell Types; 3.2. Modulating Beneficial vs. Detrimental Effects; 3.3. Identifying Injury-Associated Changes; 3.4. Understanding and Manipulating Regulatory Processes for Therapeutic Benefit; 3.5. The IL-6 and IL-10 Signaling Dynamic; 3.6. Therapeutic Development: Challenges of Inhibition; Conclusion; Acknowledgments; References; Neurological Complications Associated with Anti-Tumor Necrosis Factor Alpha (TNF-<U+0041>) Treatment; Abstract; Introduction; Tumor Necrosis Factor (TNF)-<U+0041>; Pathogenicity of TNF-<U+0041> in Neurological Disorder.
505	8		_aAnti-TNF-<U+0041> or TNF-<U+0041> Antagonist DrugAnti-TNF-<U+0041> and Neurological Disorders; Conclusion; References; Effect of Aging on Changes of Nociception and Cav2 1 Expression Patterns in Seven Inbred Mouse Strains; Abstract; Introduction; Materials and Methods; Animals; Nociceptive Assays; Statistical Analysis of Behavioral Tests; Real-Time qRT-PCR Analysis; Results; Pain-Related Behavioral Tests; Expression Tests of Cav2 Family Members with Real-Time qRT-PCR Assay; Discussion; Conclusion; Acknowledgments; References; Polymeric Intracorporeal Devices for the Management of Neurological Disorders.
505	8		_aAbstract1. Introduction; 2. Polymer-Based Implantable Devices for Major CNS Disorders; 2.1. Intracranial Implants; 2.1.1. Drug Delivery Approaches Employed to Traverse the Blood Brain Barrier; 2.1.1.1. Ethylene Vinyl Acetate Copolymers Avac as a Prototype; Biocompatible Polymer Employed for Local Drug Delivery to the Brain; 2.1.1.2. Silk-Based Polymers as an Alternative to Synthetic Drug Delivery-Systems for the Treatment of Epilepsy; 2.1.2. Application of Polymer-Based Implantable Devices in Parkinson's Disease; 2.1.2.1. Biocompatible Dopamine-Loaded Polymeric Matrix Device.
590			_aMaster record variable field(s) change: 050, 082
650		0	_aNervous system _xDiseases.
650		0	_aNeurology.
700	1		_aThomas, Chloe E., _eeditor of compilation.
700	1		_aMoore, Jayden R., _eeditor of compilation.
856	4	0	_uhttps://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=535131 _yKingston Hospital NHS Foundation Trust OpenAthens account holders click here for access
938			_aYBP Library Services _bYANK _n10251442
938			_aEBSCOhost _bEBSC _n535131
938			_aebrary _bEBRY _nebr10683149
938			_aProQuest Ebook Central _bEBLB _nEBL3021491
942			_n0
994			_a92 _bN$T
999			_c90993 _d90993