000 05238cam a2200637Mi 4500
001 ocn828140687
003 OCoLC
005 20221128212203.0
006 m d
007 cr |n|||||||||
008 130220s2012 nyua ob 001 0 eng d
010 _z 2012470307
040 _aYDXCP
_beng
_epn
_cYDXCP
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_dN$T
_dE7B
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_dDEBSZ
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019 _a923653835
_a1162046592
_a1300652077
_a1303349561
_a1303400874
020 _a1619428377
_q(electronic bk.)
020 _a9781619428379
_q(electronic bk.)
020 _z9781619428300
020 _z161942830X
035 _a541059
_b(N$T)
035 _a(OCoLC)828140687
_z(OCoLC)923653835
_z(OCoLC)1162046592
_z(OCoLC)1300652077
_z(OCoLC)1303349561
_z(OCoLC)1303400874
072 7 _aHEA
_x039140
_2bisacsh
072 7 _aMED
_x056000
_2bisacsh
049 _aMAIN
245 0 0 _aParkinson's disease :
_bdiagnosis, treatment, and prognosis
_c
_h[E-Book]
260 _aNew York :
_bNova Science Publishers, Inc.,
_c[2012]
300 _a1 online resource (xii, 232 pages :
_billustrations).
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aNeurodegenerative Diseases : Laboratory and Clinical Research
504 _aIncludes bibliographical references and index.
588 0 _aPrint version record.
505 0 _a""PARKINSON'S DISEASE ""; ""PARKINSON'S DISEASE ""; ""CONTENTS ""; ""PREFACE ""; ""THERAPEUTIC INTERVENTION AT CELLULAR CLEARANCE MECHANISMS: SIGNIFICANCE TO PARKINSON�a�?S DISEASE ""; ""ABSTRACT ""; ""ABBREVIATIONS ""; ""1. INTRODUCTORY REMARKS ""; ""2. INTRACELLULAR CLEARANCE MECHANISMS ""; ""2.1. The Ubiquitin Proteasome System ""; ""2.1.1. Quality Control through the Ubiquitin Proteasome System ""; ""2.1.2. Ubiquitin Proteasome System impairment in PD ""; ""2.2. The Autophagy-Lysosomal Pathway ""; ""2.2.1. Quality Control through the Autophagic- Lysosomal Pathway ""
505 8 _a""2.2.2. Autophagy- Lysosomal Pathway dysfunction in PD """"2.3. Enzymatic Proteolytic Systems ""; ""2.3.1. Quality Control through Cytosolic Proteolysis: Calpains ""; ""2.3.2. Quality Control through Mitochondrial Proteolysis: Lon, Clp-Like, AAA-Proteases ""; ""2.3.3. Enzymatic Proteolysis Disruption in PD ""; ""3. THERAPEUTIC INTERVENTIONS BASED ON THE MODULATION OF CLEARANCE MECHANISMS ""; ""3.1. Proteasomal Clearance �a�? A Target for Therapeutic Intervention ""; ""3.2. Autophagic Clearance �a�? A Target for Therapeutic Intervention ""
505 8 _a""3.3. Proteases Clearance �a�? A Target for Therapeutic Intervention """"CONCLUSION ""; ""ACKNOWLEDGMENTS ""; ""REFERENCES""; ""PARKINSON�a�?S DISEASE RELATED CHANGES OF OSCILLATORY ACTIVITY IN DISCRIMINATION TASKS ""; ""ABSTRACT ""; ""1. INTRODUCTION ""; ""2. METHODS ""; ""2.1. Experimental Procedure""; ""2.2. Analysis ""; ""3. EXPERIMENTAL RESULTS ""; ""Early (0�a�?250 ms) Post-stimulus Interval ""; ""Late (250�a�?600 ms) Post-stimulus Interval ""; ""4. DISCUSSION ""; ""CONCLUSION ""; ""REFERENCES ""
505 8 _a""NEW INSIGHTS INTO THE MECHANISM OF SLOWING OF VOLUNTARY MOVEMENTS IN PARKINSON�a�?S DISEASE """"ABSTRACT ""; ""ABBREVIATIONS ""; ""1. INTRODUCTION""; ""2. ANATOMIC ORGANIZATION OF THE BASAL GANGLIA ""; ""2.1. General Organization ""; ""2.2. Input and Output of Striatum and SNpc Connections ""; ""2.3. Input and Output of GP and SNpr, and STN Connections ""; ""2.4. Summary ""; ""3. PHYSIOLOGICAL FINDINGS OF THE BASAL GANGLIA IN ANIMALS ""; ""3.1. Neuronal Activity in Striatum, GPe and GPi ""; ""3.2. Neuronal Activity in STN, SNpc and SNpr ""
505 8 _a""3.3. Sequential Motor Actions and the Basal Ganglia""""3.4. Summary ""; ""4. CLINICAL SYMPTOMS OF PARKINSON�a�?S DISEASE ""; ""4.1. Slowness of Movement and Abnormal Movement Sequence ""; ""4.2. Impaired Synergy of Movement/Posture and Freezing, Loss of Postural Reflex and Festination""; ""4.3. Prolongation of Reaction Time ""; ""4.4. Reorganized Voluntary Eye Hand Coordinated Movement""; ""4.5. Impaired Time Perception and Reproduction ""; ""4.6. Summary ""; ""5. FUNCTIONAL CONSIDERATIONS OF SPATIO-TEMPORAL PROCESSING FOR MOVEMENT SYNERGY IN THE BASAL GANGLIA AND PARKINSON�a�?S DISEASE ""
546 _aEnglish.
590 _aWorldCat record variable field(s) change: 650
650 0 _aParkinson's disease.
650 0 _aSymptomatic Parkinson's disease.
650 0 _aBrain
_xDiseases.
650 2 _aBrain Diseases
650 2 _aParkinson Disease
650 2 _aParkinson Disease, Secondary
700 1 _aYoshida, Chiyo.
700 1 _aIto, Ami.
830 0 _aNeurodegenerative diseases--laboratory and clinical research.
856 4 0 _uhttps://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=541059
_yKingston Hospital NHS Foundation Trust OpenAthens account holders click here for access
938 _aProQuest Ebook Central
_bEBLB
_nEBL3017811
938 _aebrary
_bEBRY
_nebr10654782
938 _aEBSCOhost
_bEBSC
_n541059
938 _aYBP Library Services
_bYANK
_n7422447
942 _n0
994 _a92
_bN$T
999 _c91053
_d91053