000			04927cam a2200589 i 4500
001			ocn960447053
003			OCoLC
005			20221128212335.0
006			m d
007			cr |||||||||||
008			130408s2013 nyua ob 001 0 eng
010			_a 2019713811
040			_aDLC _beng _erda _cDLC _dOCLCF _dYDX _dOCLCO _dN$T _dE7B _dEBLCP _dYDXCP _dOTZ _dUAB _dAU@ _dSTF
019			_a854768436 _a923670027
020			_a9781626187979 _qebook
020			_a1626187975
020			_z1626187479 _qhbk.
020			_z9781626187474 _qhbk.
035			_a610688 _b(N$T)
035			_a(OCoLC)960447053 _z(OCoLC)854768436 _z(OCoLC)923670027
042			_apcc
072		7	_aHEA _x039140 _2bisacsh
072		7	_aMED _x056000 _2bisacsh
049			_aMAIN
245	0	0	_aDrosophila melanogaster models of motor neuron disease _c _h[E-Book]
264		1	_aNew York : _bNova Biomedical, _c[2013]
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aNeurodegenerative diseases-laboratory and clinical research
504			_aIncludes bibliographical references and index.
588			_aDescription based on print version record.
505	0		_aDROSOPHILA MELANOGASTER MODELS OF MOTOR NEURON DISEASE ; DROSOPHILA MELANOGASTER MODELS OF MOTOR NEURON DISEASE ; Library of Congress Cataloging-in-Publication Data ; CONTENTS ; PREFACE ; A RESPONSIBLE CHOICE OF MODEL ORGANISM ; Chapter 1 GENETICS OF MOTOR NEURON DISORDERS: FROM GENE DIVERSITY TO COMMON CELLULAR CONSPIRATORS IN SELECTIVE NEURONAL KILLING ; ABSTRACT ; ABBREVIATIONS ; INTRODUCTION ; 1. AMYOTROPHIC LATERAL SCLEROSIS ; 1.1. Common Pathogenic Mechanisms in ALS ; 1.1.1. Oxidative Stress and Mitochondrial Dysfunction; 1.1.2. Dysregulated Intracellular Membrane Trafficking.
505	8		_a1.1.3. Abnormal Axonal Transport and Cytoskeleton 1.1.4. Defective RNA Processing ; 1.1.5. Impaired proteostasis ; 2. HEREDITARY SPASTIC PARAPLEGIA ; 2.1. Common Pathogenic Mechanisms in HSP ; 2.1.1. Oxidative Stress and Mitochondrial Dysfunction ; 2.1.2. Dysregulated Intracellular Membrane Trafficking ; 2.1.3. Abnormal Axonal Transport and Cytoskeleton; 2.1.4. Defective Myelination and Lipid Metabolism; 3. CHARCOT-MARIE-TOOTH DISEASE ; 3.1. Common Pathogenic Mechanisms in CMT2 ; 3.1.1. Oxidative Stress and Mitochondrial Dysfunction ; 3.1.2. Dysregulated Intracellular Membrane Trafficking.
505	8		_a3.1.3. Abnormal Axonal Transport and Cytoskeleton 3.1.4. Defective Myelination and Lipid Metabolism ; 3.1.5. Impaired proteostasis ; 5. SPINAL MUSCULAR ATROPHIES AND OTHER MOTOR NEURON DISORDERS ; 5.1. Common Pathogenic Mechanisms in SMA and Other MNDs ; 5.1.1. Dysregulated Intracellular Membrane Trafficking ; 5.1.2. Abnormal Axonal Transport and Cytoskeleton ; 5.1.3. Defective RNA Processing ; 5.1.4. Impaired Proteostasis ; CONCLUSION ; ACKNOWLEDGMENTS ; ABOUT THE AUTHORS ; REFERENCES.
505	8		_aChapter 2 A SECRETED LIGAND FOR GROWTH CONE RECEPTORS, VAP MEDIATES THE CELLULAR PATHOLOGICAL DEFECTS IN ALS ABSTRACT; ABBREVIATIONS ; INTRODUCTION ; STUDIES ON MUTATIONS ASSOCIATED WITH FAMILIAL FORMS OF ALS ENABLE US TO UNDERSTAND THE CORE PATHOLOGY OF ALS ; DOMINANTLY INHERITED MISSENSE MUTATIONS IN VAP ARE ASSOCIATED WITH A FAMILIAL FORM OF ALS ; VAP IS AN ER TRANSMEMBRANE PROTEIN CONTAINING A MSP DOMAIN ; VAP FUNCTIONS IN NOVEL SIGNALLING PATHWAYS ; CLEAVAGE OF VAP RELEASES MSP DOMAIN-CONTAINING FRAGMENTS THAT ARE SECRETED.
505	8		_aVAP ACTS AS A LIGAND FOR EPH RECEPTOR AND MEDIATES EPH SIGNALLING VAP MSP MEDIATES ROBO AND LAR RECEPTORS AND FUNCTIONS IN THE MAINTENANCE OF THE MITOCHONDRIA IN MUSCLE ; ALS MUTATION CAUSES TWO DIFFERENT TYPES OF DEFECTS: A FAILURE OF VAP SECRETION (LOSS-OF-FUNCTION) AND ER STRESS (GAIN-OF-FUNCTION) AND ER STRESS (GAIN-OF-FUNCTION OR TOXIC DEFECTS) ; CONCLUSION ; ABOUT THE AUTHORS ; REFERENCES ; Chapter 3 FLIES IN MOTION: WHAT DROSOPHILA CAN TELL US ABOUT AMYOTROPHIC LATERAL SCLEROSIS ; ABSTRACT ; INTRODUCTION ; ALS IN MODEL ORGANISMS: YEAST TO MICE ; Current Hypotheses for ALS.
590			_aMaster record variable field(s) change: 072 - OCLC control number change
650		0	_aAmyotrophic lateral sclerosis. _95191
650		0	_aMotor neurons _xModels.
650		0	_aDrosophila melanogaster.
700	1		_aCauchi, Ruben J., _eeditor.
830		0	_aNeurodegenerative diseases--laboratory and clinical research.
856	4	0	_uhttps://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=610688 _yKingston Hospital NHS Foundation Trust OpenAthens account holders click here for access
938			_aYBP Library Services _bYANK _n10868042
938			_aEBL - Ebook Library _bEBLB _nEBL3022817
938			_aebrary _bEBRY _nebr10735437
938			_aEBSCOhost _bEBSC _n610688
942			_n0
994			_a92 _bN$T
999			_c91324 _d91324