000			04966cam a2200613 i 4500
001			ocn857060612
003			OCoLC
005			20221128212349.0
006			m d
007			cr |||||||||||
008			130514s2013 nyua ob 001 0 eng
010			_a 2020676671
040			_aDLC _beng _erda _cDLC _dN$T _dYDXCP _dOCLCF _dEBLCP _dAU@ _dSTF _dE7B
019			_a1058234630
020			_a9781628081657 _qpdf
020			_a1628081651
020			_z1628081597 _qhbk.
020			_z9781628081596 _qhbk.
035			_a620125 _b(N$T)
035			_a(OCoLC)857060612 _z(OCoLC)1058234630
072		7	_aHEA _x039000 _2bisacsh
072		7	_aMED _x014000 _2bisacsh
072		7	_aMED _x022000 _2bisacsh
072		7	_aMED _x112000 _2bisacsh
072		7	_aMED _x045000 _2bisacsh
049			_aMAIN
245	0	0	_aNeurofibromatosis type 1 : _bsymptoms, treatment and prognosis _c _h[E-Book]
264		1	_aNew York : _bNova Biomedical, _c[2013]
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aGenetics-Research and issues
504			_aIncludes bibliographical references and index.
588			_aDescription based on print version record.
505	0		_aNEUROFIBROMATOSIS TYPE 1 ; Library of Congress Cataloging-in-Publication Data; Contents ; Acknowledgment ; Introduction ; Chapter I Molecular Pathogenesis of Neurofibromatosis Type 1 ; Abstract ; Introduction ; Epidemiology of NF1 ; Clinical Features of NF1 ; Skin Manifestations ; Skeletal and Osseous Abnormalities ; Vascular Lesions ; Psychiatric Disorders and Cognitive Dysfunction; Rare Manifestations ; RASopathies ; Dysplasia and Developmental Defects ; Molecular Genetics of NF1 ; Genetic Diagnosis ; Tumors Associated with NF1 ; Disease Modifier Genes in NF1.
505	8		_aMolecular Pathogenesis of NF1Using Systems Approaches to Study NF1 ; Current Treatment and Disease Management ; Conclusion ; References ; Chapter II Imaging of Plexiform Neurofibromas in Neurofibromatosis Type 1 ; Abstract ; Introduction ; Imaging Appearance of Plexiform Neurofibromas ; Plexiform Neurofibroma Types ; Volumetric Analysis ; Cranial Nerves ; Spinal Nerves ; Neck, Mediastinum, Chest ; Abdomen, Pelvis ; Malignant Peripheral Nerve Sheath Tumors (MPNSTs) ; Conclusion ; References ; Chapter III Surgical Treatment of GiantNeurofibromas ; Abstract ; Introduction.
505	8		_aSurgical Techniques Discussion ; Conclusion ; References ; Chapter IV Neurofibromatosis Type 1-Associated Nervous System Tumors and Current Treatment Strategies ; Abstract ; Introduction ; Central Nervous System Tumors in Children with NF1 ; Low Grade Glioma: Clinical Presentation ; Low Grade Glioma: Imaging Characteristics ; Low Grade Glioma: Prognosis ; Low Grade Glioma: Treatment Modalities ; 1. Role of Surgery ; 2. Radiation Therapy ; 3. Chemotherapy; 4. Targeted Therapy ; RAS-MAPK Pathway; Peripheral Nervous System Tumors in Children with NF1.
505	8		_aPlexiform Neurofibromas: Clinical Presentation Plexiform Neurofibromas: Imaging Characteristics ; Plexiform Neurofibromas: Prognosis ; Plexiform Neurofibromas: Treatment Modalities ; 1. Role of Surgery ; 2. Radiation Therapy ; 3. Chemotherapy ; 4. Targeted Therapy ; a) mTOR Pathway ; Interferon Treatment ; b) Anti-angiogenic Treatment ; c) Tyrosine Kinase Inhibitor Treatment ; Malignant Peripheral Nerve Sheath Tumor (MPNST): Clinical Presentation ; MPNST: Imaging Characteristics ; MPNST: Prognosis ; MPNST: Treatment Modalities ; 1. Role of Surgery ; 2. Radiation Therapy ; 3. Chemotherapy.
505	8		_a4. Targeted Therapy a) Tyrosine Kinase Inhibitor Treatment; b) Angiogenic Pathways ; c) Cytoskeletal Remodeling ; Conclusion ; References ; Chapter V Outcome Measures for Optic Pathway Gliomas ; Abstract ; Introduction ; Epidemiology of OPGs ; Presentation of OPGs ; Clinical Symptoms ; Diagnostic Imaging ; Pathology ; Management of OPGs ; Clinical Course ; Surveillance ; Treatment ; Outcome Measures ; Anatomical Outcomes (MRI) ; Visual Outcomes ; Alternative Outcome Measures ; Diffusion and Perfusion Imaging; Diffusion Tensor Imaging ; Positron Emission Tomography.
590			_aWorldCat record variable field(s) change: 050
650		0	_aNeurofibromatosis. _97119
650		0	_aNeurofibromatosis in children.
700	1		_aKarajannis, Matthias A., _eeditor.
700	1		_aAllen, Jeffrey, _eeditor.
830		0	_aGenetics--research and issues series.
856	4	0	_uhttps://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=620125 _yKingston Hospital NHS Foundation Trust OpenAthens account holders click here for access
938			_aYBP Library Services _bYANK _n10737397
938			_aEBSCOhost _bEBSC _n620125
938			_aebrary _bEBRY _nebr10740747
938			_aProQuest Ebook Central _bEBLB _nEBL3022879
942			_n0
994			_a92 _bN$T
999			_c91369 _d91369