000			02128nam a2200349 i 4500
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005			20231010110638.0
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008			230118s2020 enka fob 001|0|eng|d
020			_a9781912776801 (PDF ebook) : _cNo price
020			_z9781912776795 (pbk.) : _cNo price
020			_z9781912776801
040			_aStDuBDS _beng _cStDuBDS _erda _epn
060		4	_aWG 540
100	1		_aScully, Marie A., _eauthor.
245	1	0	_aThrombotic thrombocytopenic purpura / _h[e-book]
264		1	_aAbingdon, Oxford : _bKarger, _c2020.
300			_a1 online resource (60 pages) : _billustrations (colour).
490	1		_aFast facts
500			_aAlso issued in print: 2020.
504			_aIncludes bibliographical references and index.
520	8		_aThrombotic thrombocytopenic purpura (TTP) is a rare disorder of the blood coagulation system. In most cases, a lack of the ADAMTS13 enzyme leads to an accumulation of ultra-large von Willebrand factor molecules in the plasma which, in turn, initiate the formation of microscopic thromboses in small blood vessels. TTP is a medical emergency. Timely diagnosis and urgent and effective management are vital - mortality in those untreated is in the region of 90%. The understanding of TTP pathogenesis has increased markedly in recent decades. It is now known that TTP is acquired (immunemediated) or congenital, and that the most common type - the acquired form - predominantly affects women in their 40s. It is also clear that the prompt delivery of plasma exchange saves lives.
521			_aSpecialized.
588			_aDescription based on online resource; title from PDF title page (viewed on January 18, 2023).
650		0	_aThrombotic thrombocytopenic purpura.
650		2	_aPurpura, Thrombotic Thrombocytopenic.
700	1		_aCataland, Spero R., _eauthor.
830		0	_aFast facts.
856	4	0	_uhttps://app.kortext.com/Shibboleth.sso/Login?entityID=https://idp.eng.nhs.uk/openathens&target=https://app.kortext.com/borrow/2133368 _yEligible NHS OpenAthens account holders click here for access
999			_c96817 _d96817